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• W2002252116 abstract "Gastric outlet obstruction (GOO) is a complication of advanced gastric, periampullary and duodenal malignancies. Palliation of symptoms of obstruction is the primary aim of treatment in these patients. Self-expandable metal stents have emerged as a promising treatment option. Methods: The aim of this prospective multicentre study was to investigate the efficacy of a new enteral stent (WallFlex™, Boston Scientific, Natick, MA, USA) in patients with symptoms from malignant gastro-duodenal obstruction due to incurable distal gastric, periampullary or duodenal malignancy. Consecutive patients who fulfilled the patient selection criteria and presenting at one of the participating hospitals between January 1st 2005 and February 1st 2006 were included. In case of biliary obstruction, adequate drainage of the biliary tree with metal stents was achieved prior to stenting. Patients were followed until death. GOO-symptoms were defined as early satiety and/or nausea and/or vomiting and/or inability to eat. Study endpoints were: technical success (successful stent placement and deployment), clinical success (relief of symptoms and/or improvement of Gastric Outlet Obstruction Scoring System (GOOSS)-score) and intervention-related complications.Results: A total of 51 patients were included (25 male, mean age 68 years). The main cause of GOO was pancreatic cancer (35 patients, 69%). Combined endoscopic/fluoroscopic stent placement was technically successful in 50 patients (98%); in 1 patient the stent needed to be dilated to deploy sufficiently. The GOOSS-score improved significantly (Wilcoxon signed ranks test - two-sided; p < 0.0001) when comparing the score prior to stenting with the mean score during the remainder of lives. All patients were followed until death. Median survival was 62 days (interquartile range (IQR) 121 days). Oral intake was resumed at a median of 0 days (IQR 1 day) after stent placement. Median procedure-related hospitalization time was 3 days (IQR 5 days). There were 7 stent-related complications: 6 (11.8%) due to tumor over- or ingrowth (respectively n = 1 and n = 5) at a median of 121 days (IQR 280 days) and 1 due to stent migration (2%), 13 days after stent placement. These were all treated by additional stent placement. Conclusion: This single-arm prospective cohort study showed that placement of a WallFlex enteral stent in patients with non-resectable malignant GOO is safe and provides a significant relief of obstructive symptoms." @default.
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• W2002252116 date "2008-04-01" @default.
• W2002252116 modified "2023-10-16" @default.
• W2002252116 title "Final Results of a Prospective Multicentre, Clinical Study On the Efficacy of the New WallFlex Enteral Stent in Malignant Gastric Outlet Obstruction (DUOFLEX)" @default.
• W2002252116 doi "https://doi.org/10.1016/j.gie.2008.03.272" @default.
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