Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002253107> ?p ?o ?g. }
- W2002253107 endingPage "328" @default.
- W2002253107 startingPage "319" @default.
- W2002253107 abstract "Early, accurate detection of small-cell lung cancer (SCLC), before it becomes systemic, is essential for successful treatment. Fluorescence-based imaging provides safe, sensitive detection of malignancies. Targeted delivery of fluorophores increases sensitivity of endoscopic imaging. We synthesized novel somatostatin analogs, based on backbone cyclic peptides, and conjugated them with fluorescent agents. Nineteen conjugates differing in core peptide, length of alkyl linker and fluorescence moiety (rhodamine and fluorescein) were tested in vitro, using a receptor binding assay, and nine of the more promising conjugates were tested in vivo by fiber-optic spectrofluorimetry and quantitative spectral imaging, on an H69 human SCLC tumor mouse xenograft model. The lead compound showed exceptional tumor/normal tissue ratios, ranging from 9 to 90, and has potential for targeting SCLC overexpressing somatostatin receptors." @default.
- W2002253107 created "2016-06-24" @default.
- W2002253107 creator A5010664740 @default.
- W2002253107 creator A5022930343 @default.
- W2002253107 creator A5031344614 @default.
- W2002253107 creator A5041017326 @default.
- W2002253107 creator A5049671447 @default.
- W2002253107 creator A5074178076 @default.
- W2002253107 creator A5076208424 @default.
- W2002253107 creator A5082291649 @default.
- W2002253107 date "2005-12-01" @default.
- W2002253107 modified "2023-10-10" @default.
- W2002253107 title "Targeting small-cell lung cancer with novel fluorescent analogs of somatostatin" @default.
- W2002253107 cites W1530960014 @default.
- W2002253107 cites W1534575982 @default.
- W2002253107 cites W1584743295 @default.
- W2002253107 cites W1966587308 @default.
- W2002253107 cites W1974040309 @default.
- W2002253107 cites W1975307947 @default.
- W2002253107 cites W1982393289 @default.
- W2002253107 cites W1986329935 @default.
- W2002253107 cites W1990148629 @default.
- W2002253107 cites W1990972541 @default.
- W2002253107 cites W1992184918 @default.
- W2002253107 cites W1999337540 @default.
- W2002253107 cites W2011145566 @default.
- W2002253107 cites W2023524492 @default.
- W2002253107 cites W2026052909 @default.
- W2002253107 cites W2030678976 @default.
- W2002253107 cites W2040042682 @default.
- W2002253107 cites W2047581019 @default.
- W2002253107 cites W2048179918 @default.
- W2002253107 cites W2075940287 @default.
- W2002253107 cites W2077308771 @default.
- W2002253107 cites W2086936581 @default.
- W2002253107 cites W2094890137 @default.
- W2002253107 cites W2095153351 @default.
- W2002253107 cites W2108890327 @default.
- W2002253107 cites W2108899627 @default.
- W2002253107 cites W2146941024 @default.
- W2002253107 cites W2155437382 @default.
- W2002253107 cites W2169378232 @default.
- W2002253107 cites W2323027000 @default.
- W2002253107 doi "https://doi.org/10.1016/j.lungcan.2005.07.009" @default.
- W2002253107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16159681" @default.
- W2002253107 hasPublicationYear "2005" @default.
- W2002253107 type Work @default.
- W2002253107 sameAs 2002253107 @default.
- W2002253107 citedByCount "35" @default.
- W2002253107 countsByYear W20022531072012 @default.
- W2002253107 countsByYear W20022531072013 @default.
- W2002253107 countsByYear W20022531072014 @default.
- W2002253107 countsByYear W20022531072015 @default.
- W2002253107 countsByYear W20022531072016 @default.
- W2002253107 countsByYear W20022531072017 @default.
- W2002253107 countsByYear W20022531072018 @default.
- W2002253107 countsByYear W20022531072020 @default.
- W2002253107 countsByYear W20022531072021 @default.
- W2002253107 countsByYear W20022531072023 @default.
- W2002253107 crossrefType "journal-article" @default.
- W2002253107 hasAuthorship W2002253107A5010664740 @default.
- W2002253107 hasAuthorship W2002253107A5022930343 @default.
- W2002253107 hasAuthorship W2002253107A5031344614 @default.
- W2002253107 hasAuthorship W2002253107A5041017326 @default.
- W2002253107 hasAuthorship W2002253107A5049671447 @default.
- W2002253107 hasAuthorship W2002253107A5074178076 @default.
- W2002253107 hasAuthorship W2002253107A5076208424 @default.
- W2002253107 hasAuthorship W2002253107A5082291649 @default.
- W2002253107 hasConcept C111919701 @default.
- W2002253107 hasConcept C121332964 @default.
- W2002253107 hasConcept C12554922 @default.
- W2002253107 hasConcept C126322002 @default.
- W2002253107 hasConcept C134306372 @default.
- W2002253107 hasConcept C1491633281 @default.
- W2002253107 hasConcept C150903083 @default.
- W2002253107 hasConcept C170493617 @default.
- W2002253107 hasConcept C185592680 @default.
- W2002253107 hasConcept C197336794 @default.
- W2002253107 hasConcept C202751555 @default.
- W2002253107 hasConcept C207001950 @default.
- W2002253107 hasConcept C2776297358 @default.
- W2002253107 hasConcept C2776568683 @default.
- W2002253107 hasConcept C2778015030 @default.
- W2002253107 hasConcept C2779916640 @default.
- W2002253107 hasConcept C2780557392 @default.
- W2002253107 hasConcept C33923547 @default.
- W2002253107 hasConcept C41008148 @default.
- W2002253107 hasConcept C502942594 @default.
- W2002253107 hasConcept C55493867 @default.
- W2002253107 hasConcept C57477423 @default.
- W2002253107 hasConcept C62520636 @default.
- W2002253107 hasConcept C71240020 @default.
- W2002253107 hasConcept C71924100 @default.
- W2002253107 hasConcept C80115893 @default.
- W2002253107 hasConcept C86803240 @default.
- W2002253107 hasConcept C91881484 @default.
- W2002253107 hasConceptScore W2002253107C111919701 @default.
- W2002253107 hasConceptScore W2002253107C121332964 @default.