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• W2002253119 abstract "The interactions of synthetically produced gold nanoparticles (GNPs) with living organisms are getting attention in the biomedical sciences. While non-viral vectors, like GNPs, are safer and more cost- efficient than viral vectors, the efficiency of cell penetration and nuclear delivery are lower. The nucleus of the cell is an important target in medical applications, such as cancer therapy and gene therapy. However, targeted nuclear delivery is a challenging task due to the two barriers the GNPs have to pass - the cellular membrane and nuclear membrane barrier. Unmodified GNPs enter the cell through a receptor-medicated endocytosis (RME), encapsulated in an endosome. Various peptide sequences are conjugated onto GNPs for modification, to bypass RME (direct cell membrane penetration) and target the nucleus of the cell. The transport of GNP-peptide complexes can be tracked and studied under different conditions to improve therapeutics." @default.
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• W2002253119 date "2014-01-01" @default.
• W2002253119 modified "2023-09-28" @default.
• W2002253119 title "Gold Nanoparticle Modification for Nuclear Targeting" @default.
• W2002253119 doi "https://doi.org/10.1016/j.bpj.2013.11.1267" @default.
• W2002253119 hasPublicationYear "2014" @default.
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