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• W2002254512 abstract "The chronotropic and inotropic effects of muscarinic receptor agonists (Acetylcholine, Arecoline, Carbachol, Furtrethonium) and antagonists (Atropine, N-methyl and N-butyl scopolammonium, pirenzepine) on isolated guinea-pig atria were studied. All had a greater affinity constants for muscarinic receptors as assessed in terms of inotropic effects than in terms of chronotropic effects. This difference, well correlated with the pharmacological effect, suggests the occurrence of cardiac muscarinic receptor subtypes, one mediating heart rate and the other contractile force. The ratio of chronotropic to inotropic potencies for each agent shows that the physiological mediator, Acetylcholine, differentiates best between the two subtypes, while atropine is the least discriminatory." @default.
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• W2002254512 date "1984-10-01" @default.
• W2002254512 modified "2023-10-18" @default.
• W2002254512 title "Pharmacological evidence for cardiac muscarinic receptor subtypes" @default.
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• W2002254512 doi "https://doi.org/10.1016/0024-3205(84)90270-4" @default.
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