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- W2002255145 abstract "In our attempt to optimize the synthesis of cis-dichlorodiammineplatinum(H) (cisplatin, DDP), a widely used anticancer drug, we needed a simple, rapid, specific and sensitive determination of this compound. High-performance liquid chromatography coupled with pre-column derivatization’, post-column derivatization2, polarographic detection3 and flameless atomic absorption spectrophotometry (FAAS)4 have been used to determine cisplatin in various matrices. These methods are specific and sensitive, but have several disadvantages. While some of them are time-consuming, others are more sophisticated and tedious. Qualitative work with flat-bed chromatography methods has been successfully used. Basolo et aL5 described the use of solvent mixtures of water and acetone or ethanol on cellulose filter paper to separate the ctiand trans-[Pt(NHX it also provides a simple and sensitive technique for the quantitative determination of cisplatin." @default.
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- W2002255145 date "1984-01-01" @default.
- W2002255145 modified "2023-09-26" @default.
- W2002255145 title "Quantitative analysis of cis-dichlorodiammineplatinum(II) by high-performance thin-layer chromatography" @default.
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- W2002255145 doi "https://doi.org/10.1016/s0021-9673(01)90774-5" @default.
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