Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002257898> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2002257898 endingPage "166" @default.
- W2002257898 startingPage "166" @default.
- W2002257898 abstract "The overexpression of the human epidermal growth factor receptor type 2 (HER-2) is an independent prognostic factor of poor outcome in patients with breast cancer. Two compounds have been registered for HER-2-positive tumour treatment: trastuzumab, a humanised antibody directed against the HER-2 extracellular domain, and lapatinib, a small molecule acting as a dual EGF-R and HER-2 tyrosine kinase inhibitor. Although both drugs improve progression-free survival, many patients’ tumours will exhibit primary resistance, or develop secondary resistance, to anti-HER-2 therapies. The recent significant improvement of survival gained with pertuzumab (an antibody disrupting dimerisation of the receptor) or trastuzumab emtansine (T-DM1, a cytotoxic drug vectored by trastuzumab binding) opened the way for new registrations.This review describes the molecular mechanisms by which tumour cells may adapt to and evade HER-2 inhibition by HER-2-targeted therapies and discusses strategies to prevent and overcome resistance to trastuzumab and lapatinib. These strategies may include the establishment of predictive markers, exploration of combination therapies and modulation of nodal targets." @default.
- W2002257898 created "2016-06-24" @default.
- W2002257898 creator A5086971801 @default.
- W2002257898 date "2008-04-01" @default.
- W2002257898 modified "2023-10-14" @default.
- W2002257898 title "Organisation of breast units" @default.
- W2002257898 doi "https://doi.org/10.1016/s1359-6349(08)70704-3" @default.
- W2002257898 hasPublicationYear "2008" @default.
- W2002257898 type Work @default.
- W2002257898 sameAs 2002257898 @default.
- W2002257898 citedByCount "0" @default.
- W2002257898 crossrefType "journal-article" @default.
- W2002257898 hasAuthorship W2002257898A5086971801 @default.
- W2002257898 hasConcept C101544691 @default.
- W2002257898 hasConcept C121608353 @default.
- W2002257898 hasConcept C126322002 @default.
- W2002257898 hasConcept C143998085 @default.
- W2002257898 hasConcept C170493617 @default.
- W2002257898 hasConcept C2775930923 @default.
- W2002257898 hasConcept C2777329042 @default.
- W2002257898 hasConcept C2778087150 @default.
- W2002257898 hasConcept C2778820342 @default.
- W2002257898 hasConcept C2779438470 @default.
- W2002257898 hasConcept C2779786085 @default.
- W2002257898 hasConcept C2781164504 @default.
- W2002257898 hasConcept C2908728163 @default.
- W2002257898 hasConcept C2994294914 @default.
- W2002257898 hasConcept C42362537 @default.
- W2002257898 hasConcept C502942594 @default.
- W2002257898 hasConcept C530470458 @default.
- W2002257898 hasConcept C71924100 @default.
- W2002257898 hasConceptScore W2002257898C101544691 @default.
- W2002257898 hasConceptScore W2002257898C121608353 @default.
- W2002257898 hasConceptScore W2002257898C126322002 @default.
- W2002257898 hasConceptScore W2002257898C143998085 @default.
- W2002257898 hasConceptScore W2002257898C170493617 @default.
- W2002257898 hasConceptScore W2002257898C2775930923 @default.
- W2002257898 hasConceptScore W2002257898C2777329042 @default.
- W2002257898 hasConceptScore W2002257898C2778087150 @default.
- W2002257898 hasConceptScore W2002257898C2778820342 @default.
- W2002257898 hasConceptScore W2002257898C2779438470 @default.
- W2002257898 hasConceptScore W2002257898C2779786085 @default.
- W2002257898 hasConceptScore W2002257898C2781164504 @default.
- W2002257898 hasConceptScore W2002257898C2908728163 @default.
- W2002257898 hasConceptScore W2002257898C2994294914 @default.
- W2002257898 hasConceptScore W2002257898C42362537 @default.
- W2002257898 hasConceptScore W2002257898C502942594 @default.
- W2002257898 hasConceptScore W2002257898C530470458 @default.
- W2002257898 hasConceptScore W2002257898C71924100 @default.
- W2002257898 hasIssue "7" @default.
- W2002257898 hasLocation W20022578981 @default.
- W2002257898 hasOpenAccess W2002257898 @default.
- W2002257898 hasPrimaryLocation W20022578981 @default.
- W2002257898 hasRelatedWork W100456685 @default.
- W2002257898 hasRelatedWork W2054861834 @default.
- W2002257898 hasRelatedWork W2097845723 @default.
- W2002257898 hasRelatedWork W2481553405 @default.
- W2002257898 hasRelatedWork W2556859315 @default.
- W2002257898 hasRelatedWork W2905960639 @default.
- W2002257898 hasRelatedWork W3088751691 @default.
- W2002257898 hasRelatedWork W3100248540 @default.
- W2002257898 hasRelatedWork W3123611170 @default.
- W2002257898 hasRelatedWork W4221053062 @default.
- W2002257898 hasVolume "6" @default.
- W2002257898 isParatext "false" @default.
- W2002257898 isRetracted "false" @default.
- W2002257898 magId "2002257898" @default.
- W2002257898 workType "article" @default.