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• W200225878 abstract "The traditional surgical approach to treat drug-resistant focal epileptic patients is in the resection or disconnection of the epileptic focus. However, a significant minority of patients continue to experience seizures after surgery, which shows the incomplete level of knowledge that currently we have of this pathology.This paper introduces some concepts of functional connectivity and complex networks methodology with its application to the study of neurophysiological recordings from patients suffering from drug-resistant focal epilepsy.In order to fully understand the new developments in the area of complex networks and its applications to the study of epilepsy, we will here review fundamental concepts in complex networks methodology, synchronization and functional connectivity. Some of the most recent published works dealing with focal epilepsy viewed under this new perspective will be revised and commented.We think that a wider perspective in the study of epilepsy, such as the one reviewed in this work, will allow epileptologists to consider surgical alternatives in the usual treatment of focal epilepsy at those currently performed in most medical centers around the world. Combining the traditional knowledge with new insights provided by network theory will certainly fill many of the gaps we have today in the fragmented understanding of epilepsy.Conectividad funcional y redes complejas en el estudio de la epilepsia focal. Implicaciones fisiopatologicas y terapeuticas.Introduccion. El modelo tradicional de cirugia de la epilepsia focal consiste en la localizacion y reseccion de la zona epileptogena. Sin embargo, una minoria significativa de pacientes epilepticos sigue teniendo crisis tras la reseccion, lo que muestra el nivel de conocimiento incompleto que actualmente se tiene sobre esta materia. Objetivo. Introducir algunos conceptos de conectividad funcional y redes complejas y su aplicacion al estudio de registros neurofisiologicos de pacientes con epilepsia focal farmacorresistente, principalmente del lobulo temporal. Desarrollo. Con el objeto de entender con plenitud los nuevos desarrollos en el area de redes complejas y sus aplicaciones al estudio de la epilepsia, se revisaran los conceptos fundamentales de la metodologia de redes complejas, sincronizacion y conectividad funcional. Asimismo, se revisaran algunos de los trabajos mas recientes en los que se analizan registros neurofisiologicos y resonancias funcionales de pacientes con epilepsia focal bajo esta nueva perspectiva. Conclusiones. Una vision mas amplia en la perspectiva para el entendimiento de la epilepsia focal, como la tratada en este trabajo, permitira tambien plantear nuevas alternativas al tratamiento quirurgico de la epilepsia focal, tanto con el desarrollo de nuevos metodos no invasivos como con la mejora y optimizacion de algunos de los metodos invasivos ya existentes." @default.
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• W200225878 date "2014-01-01" @default.
• W200225878 modified "2023-10-14" @default.
• W200225878 title "Conectividad funcional y redes complejas en el estudio de la epilepsia focal. Implicaciones fisiopatológicas y terapéuticas" @default.
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• W200225878 doi "https://doi.org/10.33588/rn.5809.2013581" @default.
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