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- W2002294842 abstract "The tumor suppressor gene p53, mutated in ≈50% of all human cancers, encodes a sequence-specific DNA-binding transcription factor. Target genes can be roughly categorized into two groups: genes that temporarily halt cell-cycle progression and genes that promote apoptosis. However, the molecular mechanism by which p53 senses whether to initiate cell-cycle arrest or apoptosis following cellular stress remains unknown. Here, we argue that the breast cancer tumor suppressor gene product BRCA1 might function as a molecular scaffold, assembling proteins involved in the fine-tuning of the p53 response." @default.
- W2002294842 created "2016-06-24" @default.
- W2002294842 creator A5042581048 @default.
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- W2002294842 date "2003-09-01" @default.
- W2002294842 modified "2023-09-26" @default.
- W2002294842 title "BRCA1: a scaffold for p53 response?" @default.
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- W2002294842 doi "https://doi.org/10.1016/s0168-9525(03)00193-8" @default.
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