FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002304314> ?p ?o ?g. }

• W2002304314 endingPage "510" @default.
• W2002304314 startingPage "505" @default.
• W2002304314 abstract "In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway. It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2-adrenoreceptor/PKA pathway in the prostate gland. We measured epinephrine levels in blood samples collected immediately prior to prostate biopsies and measured phosphorylation of S133CREB (PKA site), S112BAD, T202/Y204ERK, and S473 Akt in prostate biopsy tissue samples. Tissue samples and 3 ml of blood were obtained from men (n = 20) recruited from the patients scheduled for prostate biopsies. Epinephrine levels were measured by ELISA. Proteins were extracted from biopsied tissue, and protein phosphorylation was measured by Western blotting with phospho-specific antibodies. Pearson and Spearman’s rank correlations were analyzed to assess relationships between blood epinephrine levels and phosphorylation of CREB, BAD, AKT, and ERK. Epinephrine levels above 1 nM were detected in 5 of 20 patients. A strong positive correlation was observed between increased epinephrine levels and CREB phosphorylation. In contrast, no correlation was observed between epinephrine levels and phosphorylation of ERK, BAD, or AKT. Our results suggest that increased blood epinephrine levels activate the beta2-adrenoreceptor/PKA signaling pathway in human prostate glands. These results will inform future studies to examine whether beta2-selective blockers can inhibit activation of the epinephrine/ADRB2/PKA pathway in prostate tumors of men with increased epinephrine levels and explore the use of beta2-selective blockers as adjuvant therapy for prostate cancer." @default.
• W2002304314 created "2016-06-24" @default.
• W2002304314 creator A5001676288 @default.
• W2002304314 creator A5003873860 @default.
• W2002304314 creator A5025223836 @default.
• W2002304314 creator A5027561648 @default.
• W2002304314 creator A5038891678 @default.
• W2002304314 creator A5087574836 @default.
• W2002304314 creator A5087989597 @default.
• W2002304314 date "2013-09-21" @default.
• W2002304314 modified "2023-09-25" @default.
• W2002304314 title "A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies" @default.
• W2002304314 cites W1609833541 @default.
• W2002304314 cites W1970127699 @default.
• W2002304314 cites W1984127028 @default.
• W2002304314 cites W1991013286 @default.
• W2002304314 cites W2003727195 @default.
• W2002304314 cites W2004541913 @default.
• W2002304314 cites W2006590440 @default.
• W2002304314 cites W2008030719 @default.
• W2002304314 cites W2012979931 @default.
• W2002304314 cites W2013102352 @default.
• W2002304314 cites W2020961525 @default.
• W2002304314 cites W2032018235 @default.
• W2002304314 cites W2034472089 @default.
• W2002304314 cites W2043236550 @default.
• W2002304314 cites W2080347660 @default.
• W2002304314 cites W2083451024 @default.
• W2002304314 cites W2083977403 @default.
• W2002304314 cites W2137385309 @default.
• W2002304314 cites W2137562396 @default.
• W2002304314 cites W2138071274 @default.
• W2002304314 cites W2147585948 @default.
• W2002304314 doi "https://doi.org/10.1007/s11255-013-0513-0" @default.
• W2002304314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3959255" @default.
• W2002304314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24057680" @default.
• W2002304314 hasPublicationYear "2013" @default.
• W2002304314 type Work @default.
• W2002304314 sameAs 2002304314 @default.
• W2002304314 citedByCount "9" @default.
• W2002304314 countsByYear W20023043142016 @default.
• W2002304314 countsByYear W20023043142018 @default.
• W2002304314 countsByYear W20023043142019 @default.
• W2002304314 countsByYear W20023043142020 @default.
• W2002304314 countsByYear W20023043142021 @default.
• W2002304314 countsByYear W20023043142023 @default.
• W2002304314 crossrefType "journal-article" @default.
• W2002304314 hasAuthorship W2002304314A5001676288 @default.
• W2002304314 hasAuthorship W2002304314A5003873860 @default.
• W2002304314 hasAuthorship W2002304314A5025223836 @default.
• W2002304314 hasAuthorship W2002304314A5027561648 @default.
• W2002304314 hasAuthorship W2002304314A5038891678 @default.
• W2002304314 hasAuthorship W2002304314A5087574836 @default.
• W2002304314 hasAuthorship W2002304314A5087989597 @default.
• W2002304314 hasBestOaLocation W20023043142 @default.
• W2002304314 hasConcept C104317684 @default.
• W2002304314 hasConcept C11960822 @default.
• W2002304314 hasConcept C121608353 @default.
• W2002304314 hasConcept C126322002 @default.
• W2002304314 hasConcept C134018914 @default.
• W2002304314 hasConcept C1629964 @default.
• W2002304314 hasConcept C2775859304 @default.
• W2002304314 hasConcept C2775934546 @default.
• W2002304314 hasConcept C2776235491 @default.
• W2002304314 hasConcept C2780192828 @default.
• W2002304314 hasConcept C2781217009 @default.
• W2002304314 hasConcept C55493867 @default.
• W2002304314 hasConcept C71924100 @default.
• W2002304314 hasConcept C75217442 @default.
• W2002304314 hasConcept C86339819 @default.
• W2002304314 hasConcept C86803240 @default.
• W2002304314 hasConceptScore W2002304314C104317684 @default.
• W2002304314 hasConceptScore W2002304314C11960822 @default.
• W2002304314 hasConceptScore W2002304314C121608353 @default.
• W2002304314 hasConceptScore W2002304314C126322002 @default.
• W2002304314 hasConceptScore W2002304314C134018914 @default.
• W2002304314 hasConceptScore W2002304314C1629964 @default.
• W2002304314 hasConceptScore W2002304314C2775859304 @default.
• W2002304314 hasConceptScore W2002304314C2775934546 @default.
• W2002304314 hasConceptScore W2002304314C2776235491 @default.
• W2002304314 hasConceptScore W2002304314C2780192828 @default.
• W2002304314 hasConceptScore W2002304314C2781217009 @default.
• W2002304314 hasConceptScore W2002304314C55493867 @default.
• W2002304314 hasConceptScore W2002304314C71924100 @default.
• W2002304314 hasConceptScore W2002304314C75217442 @default.
• W2002304314 hasConceptScore W2002304314C86339819 @default.
• W2002304314 hasConceptScore W2002304314C86803240 @default.
• W2002304314 hasIssue "3" @default.
• W2002304314 hasLocation W20023043141 @default.
• W2002304314 hasLocation W20023043142 @default.
• W2002304314 hasLocation W20023043143 @default.
• W2002304314 hasLocation W20023043144 @default.
• W2002304314 hasOpenAccess W2002304314 @default.
• W2002304314 hasPrimaryLocation W20023043141 @default.
• W2002304314 hasRelatedWork W1551416944 @default.
• W2002304314 hasRelatedWork W1725314107 @default.
• W2002304314 hasRelatedWork W1884231116 @default.
• W2002304314 hasRelatedWork W2168798245 @default.

• next