FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002304492> ?p ?o ?g. }

• W2002304492 endingPage "1504" @default.
• W2002304492 startingPage "1495" @default.
• W2002304492 abstract "Hypoalbuminemia and hyperfibrinogenemia are frequently observed in patients with chronic renal failure (CRF) and are both associated with cardiovascular diseases. The mechanisms responsible for hypoalbuminemia and hyperfibrinogenemia in CRF are unknown.In the present study, both albumin and fibrinogen kinetics were measured in vivo in predialysis patients (N = 6), patients on peritoneal dialysis (N = 7) and control subjects (N = 8) using l-[1-13C]-valine.Plasma albumin concentration was significantly lower in patients on peritoneal dialysis compared to control subjects (P < 0.05). Plasma fibrinogen was significantly increased in both predialysis patients (P < 0.01) as well as patients on peritoneal dialysis (P < 0.001) in comparison to control subjects. In contrast to albumin, fibrinogen is only lost in peritoneal dialysate and not in urine. The absolute synthesis rates (ASR) of albumin and fibrinogen were increased in patients on peritoneal dialysis (ASR albumin, 125 +/- 9 mg/kg/day versus 93 +/- 9 mg/kg/day, P < 0.05; ASR fibrinogen, 45 +/- 4 mg/kg/day versus 29 +/- 3 mg/kg/day, P < 0.01) compared to control subjects. Albumin synthesis is strongly correlated with fibrinogen synthesis (r2 = 0.665, P < 0.0001, N = 21). In this study, the observed hypoalbuminemia in patients on peritoneal dialysis is likely not explained by malnutrition, inadequate dialysis, inflammation, metabolic acidosis, or insulin resistance. We speculate that peritoneal albumin loss is of relevance.Synthesis rate of albumin and fibrinogen are coordinately up-regulated. Both albumin and fibrinogen are lost in peritoneal dialysis fluid. To compensate protein loss, albumin synthesis is up-regulated, but the response, in contrast to predialysis patients, does not fully correct plasma albumin concentrations in peritoneal dialysis patients. The increase in fibrinogen synthesis introduces an independent risk factor for atherosclerosis, since plasma fibrinogen pool is enlarged." @default.
• W2002304492 created "2016-06-24" @default.
• W2002304492 creator A5013683272 @default.
• W2002304492 creator A5019984985 @default.
• W2002304492 creator A5020130906 @default.
• W2002304492 creator A5021227725 @default.
• W2002304492 creator A5022703767 @default.
• W2002304492 creator A5031696632 @default.
• W2002304492 creator A5040288140 @default.
• W2002304492 creator A5050223463 @default.
• W2002304492 creator A5085068425 @default.
• W2002304492 date "2003-10-01" @default.
• W2002304492 modified "2023-10-01" @default.
• W2002304492 title "Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure" @default.
• W2002304492 cites W1163747726 @default.
• W2002304492 cites W1911737363 @default.
• W2002304492 cites W1914804823 @default.
• W2002304492 cites W1971979157 @default.
• W2002304492 cites W1974070352 @default.
• W2002304492 cites W197524056 @default.
• W2002304492 cites W1975342574 @default.
• W2002304492 cites W1979720308 @default.
• W2002304492 cites W1986697275 @default.
• W2002304492 cites W1992223719 @default.
• W2002304492 cites W2005777024 @default.
• W2002304492 cites W2009048758 @default.
• W2002304492 cites W2013261295 @default.
• W2002304492 cites W2016225023 @default.
• W2002304492 cites W2022351209 @default.
• W2002304492 cites W2024498498 @default.
• W2002304492 cites W2032932944 @default.
• W2002304492 cites W2038628870 @default.
• W2002304492 cites W2043969693 @default.
• W2002304492 cites W2050331584 @default.
• W2002304492 cites W2050867551 @default.
• W2002304492 cites W2063397792 @default.
• W2002304492 cites W2064023530 @default.
• W2002304492 cites W2066809553 @default.
• W2002304492 cites W2066910356 @default.
• W2002304492 cites W2067459650 @default.
• W2002304492 cites W2068949553 @default.
• W2002304492 cites W2073572863 @default.
• W2002304492 cites W2074675717 @default.
• W2002304492 cites W2075785558 @default.
• W2002304492 cites W2077065906 @default.
• W2002304492 cites W2088009836 @default.
• W2002304492 cites W2102157397 @default.
• W2002304492 cites W2102360936 @default.
• W2002304492 cites W2103761363 @default.
• W2002304492 cites W2109804618 @default.
• W2002304492 cites W2110725780 @default.
• W2002304492 cites W2118510223 @default.
• W2002304492 cites W2122294444 @default.
• W2002304492 cites W2123498837 @default.
• W2002304492 cites W2131803294 @default.
• W2002304492 cites W2135419782 @default.
• W2002304492 cites W2138496270 @default.
• W2002304492 cites W2223917560 @default.
• W2002304492 doi "https://doi.org/10.1046/j.1523-1755.2003.00211.x" @default.
• W2002304492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12969171" @default.
• W2002304492 hasPublicationYear "2003" @default.
• W2002304492 type Work @default.
• W2002304492 sameAs 2002304492 @default.
• W2002304492 citedByCount "47" @default.
• W2002304492 countsByYear W20023044922012 @default.
• W2002304492 countsByYear W20023044922013 @default.
• W2002304492 countsByYear W20023044922016 @default.
• W2002304492 countsByYear W20023044922018 @default.
• W2002304492 countsByYear W20023044922019 @default.
• W2002304492 countsByYear W20023044922020 @default.
• W2002304492 countsByYear W20023044922021 @default.
• W2002304492 countsByYear W20023044922022 @default.
• W2002304492 countsByYear W20023044922023 @default.
• W2002304492 crossrefType "journal-article" @default.
• W2002304492 hasAuthorship W2002304492A5013683272 @default.
• W2002304492 hasAuthorship W2002304492A5019984985 @default.
• W2002304492 hasAuthorship W2002304492A5020130906 @default.
• W2002304492 hasAuthorship W2002304492A5021227725 @default.
• W2002304492 hasAuthorship W2002304492A5022703767 @default.
• W2002304492 hasAuthorship W2002304492A5031696632 @default.
• W2002304492 hasAuthorship W2002304492A5040288140 @default.
• W2002304492 hasAuthorship W2002304492A5050223463 @default.
• W2002304492 hasAuthorship W2002304492A5085068425 @default.
• W2002304492 hasBestOaLocation W20023044921 @default.
• W2002304492 hasConcept C126322002 @default.
• W2002304492 hasConcept C134018914 @default.
• W2002304492 hasConcept C165616093 @default.
• W2002304492 hasConcept C2776009029 @default.
• W2002304492 hasConcept C2776125364 @default.
• W2002304492 hasConcept C2779036427 @default.
• W2002304492 hasConcept C2779056158 @default.
• W2002304492 hasConcept C2779978075 @default.
• W2002304492 hasConcept C71924100 @default.
• W2002304492 hasConcept C90924648 @default.
• W2002304492 hasConceptScore W2002304492C126322002 @default.
• W2002304492 hasConceptScore W2002304492C134018914 @default.
• W2002304492 hasConceptScore W2002304492C165616093 @default.
• W2002304492 hasConceptScore W2002304492C2776009029 @default.

• next