FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002306086> ?p ?o ?g. }

• W2002306086 endingPage "306" @default.
• W2002306086 startingPage "297" @default.
• W2002306086 abstract "Somatotroph and thyrotroph pituitary cells share a common precursor cell expressing the transcription factor Pit1 in ontogeny. Cells expressing both thyrotropin (TSH) and growth-hormone (GH) are found in adult rat pituitary and in human pituitary adenomas in acromegaly, and these tumors contain both thyrotropin-releasing hormone (TRH) and the TRH receptors (TRHR). It has been shown that stimulation of TSH expression in primary hypothyroidism promotes changes suggestive of somatotroph to thyrotroph cell transdifferentiation. We tested this hypothesis and the role of TRH in experimental primary hypothyroidism in rats. Adult female Long-Evans rats, 6 months old, were administered the antithyroid drug methimazole (0.1% w/v) in the drinking water for 42 days. Animals were sacrificed by perfusion fixation under anaesthesia at weekly intervals and pituitary tissue processed in acrylic resin for immunofluorescence and immuno-electronmicroscopy for TSH, GH and TRHR. In the hypothyroid rat pituitary immunofluorescent somatotrophs were greatly reduced in number and gradually replaced by thyrotrophs during methimazole administration. Colocalization of GH and TSH in the same cell was noted. Immunoelectronmicroscopy demonstrated the development of enlarged thyrotrophs with dilated rough endoplasmic reticulum containing an electron-dense material and intracisternal granules, both of which are immunoreactive for TSH ('thyroidectomy cells'). The somatotrophs showed reduced GH immunoreactivity and also the presence of TSH-type, small-size secretory granules. This suggests that the greatly increased number of TSH-cells in methimazole-induced-hypothyroidism is due, at least partially, to the transdifferentiation of somatotroph into thyrotroph cells. TRHR immunofluorescence was expressed in many somatotrophs in normal rat pituitary and unlike immunoreactive GH, its expression was enhanced during hypothyroidism. The number of TRHR-immunoreactive cells increased in parallel with the number of TSH-immunoreactive cells. This indicates a role for TRH stimulation in the transdifferentiation process. Taken together, these data suggest that, in addition to the cell mutation mechanism involving an early totipotential progenitor cell, transdifferentiation of existing somatotroph cells also plays a part in the pathogenesis of multihormonal GH-secreting adenomas." @default.
• W2002306086 created "2016-06-24" @default.
• W2002306086 creator A5003096777 @default.
• W2002306086 creator A5034595806 @default.
• W2002306086 creator A5047172219 @default.
• W2002306086 date "2003-07-01" @default.
• W2002306086 modified "2023-10-10" @default.
• W2002306086 title "Somatotroph to thyrotroph cell transdifferentiation during experimental hypothyroidism - a light and electron-microscopy study" @default.
• W2002306086 cites W1650700847 @default.
• W2002306086 cites W1785489921 @default.
• W2002306086 cites W1966756004 @default.
• W2002306086 cites W1967558440 @default.
• W2002306086 cites W1970869232 @default.
• W2002306086 cites W1975248282 @default.
• W2002306086 cites W1975849046 @default.
• W2002306086 cites W1980050810 @default.
• W2002306086 cites W1994409736 @default.
• W2002306086 cites W1998891613 @default.
• W2002306086 cites W2003990388 @default.
• W2002306086 cites W2012622805 @default.
• W2002306086 cites W2013986549 @default.
• W2002306086 cites W2030784083 @default.
• W2002306086 cites W2035784909 @default.
• W2002306086 cites W2036752614 @default.
• W2002306086 cites W2043304428 @default.
• W2002306086 cites W2054004217 @default.
• W2002306086 cites W2057742849 @default.
• W2002306086 cites W2060907798 @default.
• W2002306086 cites W2061227947 @default.
• W2002306086 cites W2062502773 @default.
• W2002306086 cites W2064291743 @default.
• W2002306086 cites W2064557280 @default.
• W2002306086 cites W2070170063 @default.
• W2002306086 cites W2075900049 @default.
• W2002306086 cites W2080960652 @default.
• W2002306086 cites W2084593499 @default.
• W2002306086 cites W2086532113 @default.
• W2002306086 cites W2090906005 @default.
• W2002306086 cites W2091607263 @default.
• W2002306086 cites W2092650102 @default.
• W2002306086 cites W2092861961 @default.
• W2002306086 cites W2135676923 @default.
• W2002306086 cites W2152746599 @default.
• W2002306086 cites W2164988501 @default.
• W2002306086 cites W2171642341 @default.
• W2002306086 cites W2405466891 @default.
• W2002306086 cites W2411556630 @default.
• W2002306086 cites W2413316967 @default.
• W2002306086 cites W2417482080 @default.
• W2002306086 cites W287449298 @default.
• W2002306086 cites W2885149969 @default.
• W2002306086 cites W4241730899 @default.
• W2002306086 cites W4242322227 @default.
• W2002306086 cites W4252518899 @default.
• W2002306086 cites W4255117771 @default.
• W2002306086 cites W4255604019 @default.
• W2002306086 cites W4300440222 @default.
• W2002306086 doi "https://doi.org/10.1111/j.1582-4934.2003.tb00230.x" @default.
• W2002306086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741402" @default.
• W2002306086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14594554" @default.
• W2002306086 hasPublicationYear "2003" @default.
• W2002306086 type Work @default.
• W2002306086 sameAs 2002306086 @default.
• W2002306086 citedByCount "31" @default.
• W2002306086 countsByYear W20023060862012 @default.
• W2002306086 countsByYear W20023060862013 @default.
• W2002306086 countsByYear W20023060862014 @default.
• W2002306086 countsByYear W20023060862015 @default.
• W2002306086 countsByYear W20023060862017 @default.
• W2002306086 countsByYear W20023060862020 @default.
• W2002306086 countsByYear W20023060862021 @default.
• W2002306086 countsByYear W20023060862022 @default.
• W2002306086 crossrefType "journal-article" @default.
• W2002306086 hasAuthorship W2002306086A5003096777 @default.
• W2002306086 hasAuthorship W2002306086A5034595806 @default.
• W2002306086 hasAuthorship W2002306086A5047172219 @default.
• W2002306086 hasBestOaLocation W20023060862 @default.
• W2002306086 hasConcept C126322002 @default.
• W2002306086 hasConcept C134018914 @default.
• W2002306086 hasConcept C184760221 @default.
• W2002306086 hasConcept C2777658017 @default.
• W2002306086 hasConcept C71315377 @default.
• W2002306086 hasConcept C71924100 @default.
• W2002306086 hasConcept C86803240 @default.
• W2002306086 hasConcept C94984642 @default.
• W2002306086 hasConceptScore W2002306086C126322002 @default.
• W2002306086 hasConceptScore W2002306086C134018914 @default.
• W2002306086 hasConceptScore W2002306086C184760221 @default.
• W2002306086 hasConceptScore W2002306086C2777658017 @default.
• W2002306086 hasConceptScore W2002306086C71315377 @default.
• W2002306086 hasConceptScore W2002306086C71924100 @default.
• W2002306086 hasConceptScore W2002306086C86803240 @default.
• W2002306086 hasConceptScore W2002306086C94984642 @default.
• W2002306086 hasIssue "3" @default.
• W2002306086 hasLocation W20023060861 @default.
• W2002306086 hasLocation W20023060862 @default.
• W2002306086 hasLocation W20023060863 @default.
• W2002306086 hasLocation W20023060864 @default.

• next