Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002308570> ?p ?o ?g. }
- W2002308570 endingPage "201" @default.
- W2002308570 startingPage "182" @default.
- W2002308570 abstract "Until recently, the intrinsically high level of cross-talk between immune cells, the complexity of immune cell development, and the pleiotropic nature of cytokine signaling have hampered progress in understanding the mechanisms of immunosuppression by which tumor cells circumvent native and adaptive immune responses. One technology that has helped to shed light on this complex signaling network is the cytokine antibody array, which facilitates simultaneous screening of dozens to hundreds of secreted signal proteins in complex biological samples. The combined applications of traditional methods of molecular and cell biology with the high-content, high-throughput screening capabilities of cytokine antibody arrays and other multiplexed immunoassays have revealed a complex mechanism that involves multiple cytokine signals contributed not just by tumor cells but by stromal cells and a wide spectrum of immune cell types. This review will summarize the interactions among cancerous and immune cell types, as well as the key cytokine signals that are required for tumors to survive immunoediting in a dormant state or to grow and spread by escaping it. Additionally, it will present examples of how probing secreted cell-cell signal networks in the tumor microenvironment (TME) with cytokine screens have contributed to our current understanding of these processes and discuss the implications of this understanding to antitumor therapies." @default.
- W2002308570 created "2016-06-24" @default.
- W2002308570 creator A5006348991 @default.
- W2002308570 creator A5015981584 @default.
- W2002308570 creator A5034202621 @default.
- W2002308570 creator A5042674101 @default.
- W2002308570 creator A5048172000 @default.
- W2002308570 creator A5064840674 @default.
- W2002308570 creator A5070393024 @default.
- W2002308570 creator A5074088403 @default.
- W2002308570 creator A5075480500 @default.
- W2002308570 creator A5077630778 @default.
- W2002308570 creator A5087417941 @default.
- W2002308570 date "2014-04-01" @default.
- W2002308570 modified "2023-10-10" @default.
- W2002308570 title "Tumor-induced perturbations of cytokines and immune cell networks" @default.
- W2002308570 cites W1219680990 @default.
- W2002308570 cites W1480357432 @default.
- W2002308570 cites W1500831029 @default.
- W2002308570 cites W1511743510 @default.
- W2002308570 cites W1515725948 @default.
- W2002308570 cites W1518759830 @default.
- W2002308570 cites W1527752391 @default.
- W2002308570 cites W1661544713 @default.
- W2002308570 cites W1859257957 @default.
- W2002308570 cites W1967060514 @default.
- W2002308570 cites W1967884480 @default.
- W2002308570 cites W1967890713 @default.
- W2002308570 cites W1975568557 @default.
- W2002308570 cites W1984162437 @default.
- W2002308570 cites W1984186890 @default.
- W2002308570 cites W1984484036 @default.
- W2002308570 cites W1984706590 @default.
- W2002308570 cites W1986058292 @default.
- W2002308570 cites W1988881559 @default.
- W2002308570 cites W1988924112 @default.
- W2002308570 cites W1989595767 @default.
- W2002308570 cites W1990587639 @default.
- W2002308570 cites W1992112921 @default.
- W2002308570 cites W1993820570 @default.
- W2002308570 cites W1995481385 @default.
- W2002308570 cites W1995658981 @default.
- W2002308570 cites W1997605269 @default.
- W2002308570 cites W2001131198 @default.
- W2002308570 cites W2002157461 @default.
- W2002308570 cites W2004630197 @default.
- W2002308570 cites W2006252261 @default.
- W2002308570 cites W2012097777 @default.
- W2002308570 cites W2012704834 @default.
- W2002308570 cites W2013411992 @default.
- W2002308570 cites W2014073110 @default.
- W2002308570 cites W2021226726 @default.
- W2002308570 cites W2021580329 @default.
- W2002308570 cites W2026318599 @default.
- W2002308570 cites W2028240889 @default.
- W2002308570 cites W2028554313 @default.
- W2002308570 cites W2029650614 @default.
- W2002308570 cites W2029695719 @default.
- W2002308570 cites W2031576122 @default.
- W2002308570 cites W2037550429 @default.
- W2002308570 cites W2039146285 @default.
- W2002308570 cites W2041600831 @default.
- W2002308570 cites W2042355069 @default.
- W2002308570 cites W2043776488 @default.
- W2002308570 cites W2046972425 @default.
- W2002308570 cites W2047479954 @default.
- W2002308570 cites W2047900555 @default.
- W2002308570 cites W2049029511 @default.
- W2002308570 cites W2049491375 @default.
- W2002308570 cites W2049528074 @default.
- W2002308570 cites W2049822454 @default.
- W2002308570 cites W2049856484 @default.
- W2002308570 cites W2051099402 @default.
- W2002308570 cites W2052313621 @default.
- W2002308570 cites W2053277543 @default.
- W2002308570 cites W2056063027 @default.
- W2002308570 cites W2058648826 @default.
- W2002308570 cites W2061217549 @default.
- W2002308570 cites W2062627337 @default.
- W2002308570 cites W2064304633 @default.
- W2002308570 cites W2064920472 @default.
- W2002308570 cites W2065385505 @default.
- W2002308570 cites W2067885308 @default.
- W2002308570 cites W2068005505 @default.
- W2002308570 cites W2068994108 @default.
- W2002308570 cites W2069200323 @default.
- W2002308570 cites W2073218792 @default.
- W2002308570 cites W2073606915 @default.
- W2002308570 cites W2076866768 @default.
- W2002308570 cites W2078323166 @default.
- W2002308570 cites W2079663505 @default.
- W2002308570 cites W2080641261 @default.
- W2002308570 cites W2083991703 @default.
- W2002308570 cites W2084414513 @default.
- W2002308570 cites W2084599508 @default.
- W2002308570 cites W2088571368 @default.
- W2002308570 cites W2089828715 @default.
- W2002308570 cites W2092355198 @default.