FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002308984> ?p ?o ?g. }

• W2002308984 endingPage "e4103" @default.
• W2002308984 startingPage "e4103" @default.
• W2002308984 abstract "DNA topoisomerase II (topo II) catalyzes a strand passage reaction in that one duplex is passed through a transient brake or gate in another. Completion of late stages of neuronal development depends on the presence of active beta isoform (topo IIbeta). The enzyme appears to aid the transcriptional induction of a limited number of genes essential for neuronal maturation. However, this selectivity and underlying molecular mechanism remains unknown. Here we show a strong correlation between the genomic location of topo IIbeta action sites and the genes it regulates. These genes, termed group A1, are functionally biased towards membrane proteins with ion channel, transporter, or receptor activities. Significant proportions of them encode long transcripts and are juxtaposed to a long AT-rich intergenic region (termed LAIR). We mapped genomic sites directly targeted by topo IIbeta using a functional immunoprecipitation strategy. These sites can be classified into two distinct classes with discrete local GC contents. One of the classes, termed c2, appears to involve a strand passage event between distant segments of genomic DNA. The c2 sites are concentrated both in A1 gene boundaries and the adjacent LAIR, suggesting a direct link between the action sites and the transcriptional activation. A higher-order chromatin structure associated with AT richness and gene poorness is likely to serve as a silencer of gene expression, which is abrogated by topo IIbeta releasing nearby genes from repression. Positioning of these genes and their control machinery may have developed recently in vertebrate evolution to support higher functions of central nervous system." @default.
• W2002308984 created "2016-06-24" @default.
• W2002308984 creator A5035612576 @default.
• W2002308984 creator A5043425467 @default.
• W2002308984 creator A5047871000 @default.
• W2002308984 creator A5084680009 @default.
• W2002308984 date "2008-12-31" @default.
• W2002308984 modified "2023-10-16" @default.
• W2002308984 title "Topoisomerase IIβ Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment" @default.
• W2002308984 cites W1526379338 @default.
• W2002308984 cites W1553713926 @default.
• W2002308984 cites W1555798239 @default.
• W2002308984 cites W1559647740 @default.
• W2002308984 cites W1577222190 @default.
• W2002308984 cites W1919590537 @default.
• W2002308984 cites W1977754686 @default.
• W2002308984 cites W1983357465 @default.
• W2002308984 cites W1991149014 @default.
• W2002308984 cites W2004215286 @default.
• W2002308984 cites W2008156658 @default.
• W2002308984 cites W2014143877 @default.
• W2002308984 cites W2014547094 @default.
• W2002308984 cites W2021136272 @default.
• W2002308984 cites W2038774969 @default.
• W2002308984 cites W2060963038 @default.
• W2002308984 cites W2072467449 @default.
• W2002308984 cites W2073281700 @default.
• W2002308984 cites W2083921717 @default.
• W2002308984 cites W2085043108 @default.
• W2002308984 cites W2092638438 @default.
• W2002308984 cites W2097336416 @default.
• W2002308984 cites W2102992354 @default.
• W2002308984 cites W2118042057 @default.
• W2002308984 cites W2123202659 @default.
• W2002308984 cites W2124954099 @default.
• W2002308984 cites W2138976334 @default.
• W2002308984 cites W2147449602 @default.
• W2002308984 cites W2151338055 @default.
• W2002308984 cites W2156750696 @default.
• W2002308984 cites W2158778721 @default.
• W2002308984 cites W2217532849 @default.
• W2002308984 cites W4248318091 @default.
• W2002308984 doi "https://doi.org/10.1371/journal.pone.0004103" @default.
• W2002308984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2605559" @default.
• W2002308984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19116664" @default.
• W2002308984 hasPublicationYear "2008" @default.
• W2002308984 type Work @default.
• W2002308984 sameAs 2002308984 @default.
• W2002308984 citedByCount "54" @default.
• W2002308984 countsByYear W20023089842012 @default.
• W2002308984 countsByYear W20023089842013 @default.
• W2002308984 countsByYear W20023089842014 @default.
• W2002308984 countsByYear W20023089842015 @default.
• W2002308984 countsByYear W20023089842016 @default.
• W2002308984 countsByYear W20023089842017 @default.
• W2002308984 countsByYear W20023089842018 @default.
• W2002308984 countsByYear W20023089842019 @default.
• W2002308984 countsByYear W20023089842020 @default.
• W2002308984 countsByYear W20023089842021 @default.
• W2002308984 countsByYear W20023089842022 @default.
• W2002308984 countsByYear W20023089842023 @default.
• W2002308984 crossrefType "journal-article" @default.
• W2002308984 hasAuthorship W2002308984A5035612576 @default.
• W2002308984 hasAuthorship W2002308984A5043425467 @default.
• W2002308984 hasAuthorship W2002308984A5047871000 @default.
• W2002308984 hasAuthorship W2002308984A5084680009 @default.
• W2002308984 hasBestOaLocation W20023089841 @default.
• W2002308984 hasConcept C101762097 @default.
• W2002308984 hasConcept C104317684 @default.
• W2002308984 hasConcept C134320426 @default.
• W2002308984 hasConcept C150194340 @default.
• W2002308984 hasConcept C165864922 @default.
• W2002308984 hasConcept C53345823 @default.
• W2002308984 hasConcept C54355233 @default.
• W2002308984 hasConcept C83640560 @default.
• W2002308984 hasConcept C86803240 @default.
• W2002308984 hasConceptScore W2002308984C101762097 @default.
• W2002308984 hasConceptScore W2002308984C104317684 @default.
• W2002308984 hasConceptScore W2002308984C134320426 @default.
• W2002308984 hasConceptScore W2002308984C150194340 @default.
• W2002308984 hasConceptScore W2002308984C165864922 @default.
• W2002308984 hasConceptScore W2002308984C53345823 @default.
• W2002308984 hasConceptScore W2002308984C54355233 @default.
• W2002308984 hasConceptScore W2002308984C83640560 @default.
• W2002308984 hasConceptScore W2002308984C86803240 @default.
• W2002308984 hasIssue "12" @default.
• W2002308984 hasLocation W20023089841 @default.
• W2002308984 hasLocation W20023089842 @default.
• W2002308984 hasLocation W20023089843 @default.
• W2002308984 hasLocation W20023089844 @default.
• W2002308984 hasOpenAccess W2002308984 @default.
• W2002308984 hasPrimaryLocation W20023089841 @default.
• W2002308984 hasRelatedWork W1540936366 @default.
• W2002308984 hasRelatedWork W1969771092 @default.
• W2002308984 hasRelatedWork W2004254765 @default.
• W2002308984 hasRelatedWork W2025529750 @default.
• W2002308984 hasRelatedWork W2079625624 @default.
• W2002308984 hasRelatedWork W2125691904 @default.

• next