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• W2002313692 abstract "Diuretics are compounds which augment the flow of urine, usually by altering ionic movement across tubular epithelial cells. The present experiments were performed to determine the effects of a number of diuretics upon the rate of formation and movement of potassium into another body fluid, viz. cerebrospinal fluid (CSF). An artificial CSF was perfused through the cerebroventricular system of cats anesthetized with pentobarbital. A saline solution of radioactive potassium (42K) was infused intravenously. Following three CSF collection periods, a diuretic was injected intravenously and three more collections of CSF were made. Aminometrodine, mersalyl-theophylline, hydrochlorothiazide, chlorothiazide, triamterene, ethacrynic acid, and acetazolamide all significantly decreased the rate of CSF formation. Only spironolactone significantly increased the rate of CSF formation. A number of the diuretics significantly altered the movement of 42K into the perfusing CSF, but in a manner which did not parallel their actions on the rate of CSF formation. The processes involved in CSF formation and potassium exchange between plasma and CSF appear to be different and independent." @default.
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• W2002313692 date "1969-05-01" @default.
• W2002313692 modified "2023-10-18" @default.
• W2002313692 title "Effects of diuretics on cerebrospinal fluid formation and potassium movement" @default.
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• W2002313692 doi "https://doi.org/10.1016/0014-4886(69)90005-3" @default.
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