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W2002316265 abstract "Monocytic cells bind fibrinogen (fg) through integrin αMβ2. fg-bound monocytic cells demonstrate an enhanced adhesion to endothelial cells, which is dependent on intercellular adhesion molecule-1 (ICAM-1). Our studies differentiate fg interactions with stimulated and resting endothelial cells, which are ICAM-1 dependent and independent, respectively. This report documents a direct interaction between fg and intact ICAM-1 and with a two-Ig domain form of ICAM-1. A small region within the first Ig domain of ICAM-1, ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) (KVILPRGGSVLVTC), was identified to interact with fg in a specific and selective manner. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) bound to plasmin-derived fg fragments X, D100, and D80 but not to fragment E. Consistent with this finding, fg γ-chain peptide, fg-γ-117-133, blocked fg interaction with ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar). ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) peptide and antibodies directed against ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) also blocked the adhesion and binding of ICAM-1-bearing Raji cells with fg. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) and fg-γ-117-133 are likely to be one of the contact pairs mediating fg-ICAM-1 interactions. Monocytic cells bind fibrinogen (fg) through integrin αMβ2. fg-bound monocytic cells demonstrate an enhanced adhesion to endothelial cells, which is dependent on intercellular adhesion molecule-1 (ICAM-1). Our studies differentiate fg interactions with stimulated and resting endothelial cells, which are ICAM-1 dependent and independent, respectively. This report documents a direct interaction between fg and intact ICAM-1 and with a two-Ig domain form of ICAM-1. A small region within the first Ig domain of ICAM-1, ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) (KVILPRGGSVLVTC), was identified to interact with fg in a specific and selective manner. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) bound to plasmin-derived fg fragments X, D100, and D80 but not to fragment E. Consistent with this finding, fg γ-chain peptide, fg-γ-117-133, blocked fg interaction with ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar). ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) peptide and antibodies directed against ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) also blocked the adhesion and binding of ICAM-1-bearing Raji cells with fg. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) and fg-γ-117-133 are likely to be one of the contact pairs mediating fg-ICAM-1 interactions. While fibrinogen (fg) 1The abbreviations used are: fgfibrinogenICAM-1intercellular cell adhesion molecule 1ECendothelial cellsIgimmunoglobulinTNF-αtumor necrosis factor-αHBSSHanks' balanced salt solutionmAbmonoclonal antibodyHPLChigh pressure liquid chromatographyTBSTris-buffered salineBSAbovine serum albuminCAPS3-(cyclohexylamino)propanesulfonic acidFACSfluorescent-activated cell sortingVCAM-1vascular cell adhesion molecule-1. is a plasma protein and intracellular adhesion molecule 1 (ICAM-1) is primarily a cell surface protein, both play central roles in cell-cell interactions (1Languino L.R. Plescia J. Duperray A. Brian A.A. Plow E.F. Geltosky J.E. Altieri D.C. Cell. 1993; 73: 1423-1434Abstract Full Text PDF PubMed Scopus (287) Google Scholar, 2Springer T.A. Nature. 1990; 346: 425-434Crossref PubMed Scopus (5725) Google Scholar). fg, a dimeric 340-kDa molecule, circulates in blood at 2-3 mg/ml. It is composed of three pairs of nonidentical polypeptide chains, organized into a central E and two peripheral D domains (3Doolittle R.F. Annu. Rev. Biochem. 1984; 53: 195-229Crossref PubMed Scopus (515) Google Scholar). A cell-cell interaction that is critically dependent on fg is platelet aggregation (4Ginsberg M.H. Loftus J.C. Plow E.F. Thromb. Haemostasis. 1988; 59: 1-6Crossref PubMed Scopus (222) Google Scholar), which involves the binding of fg to platelet integrin, αIIbβ3 (5Peerschke E.I. Semin. Hematol. 1985; 22: 241-259PubMed Google Scholar). The extreme COOH-terminal aspect of the γ chain, γ-406-411, is involved in the recognition of fg by αIIbβ3 (6Kloczewiak M. Timmons S. Hawiger J. Thromb. Res. 1983; 29: 249-255Abstract Full Text PDF PubMed Scopus (79) Google Scholar). fg also interacts with other integrins, including αvβ3 and αMβ2 (7Smith J.W. Ruggeri Z.M. Kunicki T.J. Cheresh D.A. J. Biol. Chem. 1990; 265: 12267-12271Abstract Full Text PDF PubMed Google Scholar, 8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar). αvβ3 is expressed on many cell types, including endothelial cells (EC). fg recognition by this receptor is inhibited by Arg-Gly-Asp (RGD)-containing peptides, and fg has two RGD sequences within its Aα chain (3Doolittle R.F. Annu. Rev. Biochem. 1984; 53: 195-229Crossref PubMed Scopus (515) Google Scholar). Evidence is emerging to indicate that the interaction of fg with αMβ2 (Mac-1) may also be important for cell-cell interactions. fg bound to αMβ2 on leukocytes can facilitate the bridging of these cells to EC (1Languino L.R. Plescia J. Duperray A. Brian A.A. Plow E.F. Geltosky J.E. Altieri D.C. Cell. 1993; 73: 1423-1434Abstract Full Text PDF PubMed Scopus (287) Google Scholar), thereby potentially contributing to inflammatory response. Recognition of fg by αMβ2 involves a γ-chain sequence within the D domain, γ-191-202 (9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar). fibrinogen intercellular cell adhesion molecule 1 endothelial cells immunoglobulin tumor necrosis factor-α Hanks' balanced salt solution monoclonal antibody high pressure liquid chromatography Tris-buffered saline bovine serum albumin 3-(cyclohexylamino)propanesulfonic acid fluorescent-activated cell sorting vascular cell adhesion molecule-1. ICAM-1 is a member of the immunoglobulin (Ig)-like superfamily which includes several other adhesion molecules such as VCAM-1, ICAM-2, and ICAM-3. ICAM-1 (95 kDa) contains five Ig-like motifs of 80-90-amino acids which are held together by disulfide bonds (2Springer T.A. Nature. 1990; 346: 425-434Crossref PubMed Scopus (5725) Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar). Each Ig-like motif consists of seven antiparallel strands folded to form two beta sheets (12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar). ICAM-1 is present on many cell types including EC, epithelial cells, lymphocytes and macrophages (2Springer T.A. Nature. 1990; 346: 425-434Crossref PubMed Scopus (5725) Google Scholar). On EC, ICAM-1 becomes expressed on stimulation with cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1, and the bacterial product, lipopolysaccharide. ICAM-1 is a ligand for leukocyte integrins αLβ2 (LFA-1) and αMβ2 (15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar). Recognition by αLβ2 involves the first two Ig-like domains of ICAM-1, whereas αMβ2 binds to the third Ig-like repeat (17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar). These interactions with ICAM-1 facilitate leukocyte adhesion and transmigration of these cells through the endothelium (18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar). Recently, a direct interaction between fg and ICAM-1 has been demonstrated (1Languino L.R. Plescia J. Duperray A. Brian A.A. Plow E.F. Geltosky J.E. Altieri D.C. Cell. 1993; 73: 1423-1434Abstract Full Text PDF PubMed Scopus (287) Google Scholar). A mechanism can be envisioned in which fg bound to αMβ2 on leukocytes bridges to ICAM-1 on EC, thus mediating adhesion between the two cell types. This interaction has been implicated in leukocyte transmigration through endothelium (19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar). As fg-ICAM-1 interactions may have important pathophysiological ramifications, we have sought to define the molecular basis for their recognition. In this study, we describe the identification of a small sequence within ICAM-1 that is critical for its interaction with fg, specifically with γ-117-133 of fg. Furth" @default.
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W2002316265 title "Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen" @default.
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