FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002321885> ?p ?o ?g. }

• W2002321885 endingPage "266" @default.
• W2002321885 startingPage "261" @default.
• W2002321885 abstract "Abstract: Melatonin displays a dose‐dependent immunoregulatory effect in vitro and in vivo. Exogenous high‐dose melatonin therapy exerted an immunosuppressive effect, abrogating acute rejection (AR), significantly prolonging transplant survival. Endogenous melatonin secretion, in response to heterotopic rat cardiac allograft transplantation (Tx), was investigated during the AR response and under standardized immunosuppressive maintenance therapy with cyclosporin A (CsA) and rapamycin (RPM). Recipients of syngeneic transplants, and recipients of allogeneic grafts, either untreated or receiving immunosuppressive therapy constituted the experimental groups. Endogenous circadian melatonin levels were measured at 07:00, 19:00, and 24:00 hr, using a novel radioimmunoassay (RIA) procedure, under standardized 12‐hr‐light/dark‐conditions (light off: 19:00 hr; light on: 07:00 hr), before and after Tx. Neither the operative trauma, nor the challenge with a perfused allograft or the AR response influenced endogenous melatonin peak secretion. Immunosuppressive therapy with CsA led to a significant increase in peak secretion, measured for days 7 (212 ± 40.7 pg/mL; P < 0.05), 14 (255 ± 13.9 pg/mL; P < 0.001), and 21 (219 ± 34 pg/mL; P < 0.01) after Tx, as compared with naïve animals (155 ± 25.8 pg/mL). In contrast, treatment with RPM significantly decreased the melatonin peak post‐Tx up to day 7 (87 ± 25.2 pg/mL; P < 0.001), compared with naïve animals (155 ± 25.8 pg/mL). These findings imply a robust nature of the endogenous circadian melatonin secretion kinetics, even against the background of profound allogeneic stimuli. Immunosuppressive maintenance therapy with CsA and RPM modulated early melatonin secretion, indicating a specific secondary action of these drugs. Further studies are necessary to disclose the long‐term effect of immunosuppressive therapy on circadian melatonin secretion in transplant recipients." @default.
• W2002321885 created "2016-06-24" @default.
• W2002321885 creator A5013160428 @default.
• W2002321885 creator A5024795724 @default.
• W2002321885 creator A5030268815 @default.
• W2002321885 creator A5031740153 @default.
• W2002321885 creator A5039702084 @default.
• W2002321885 creator A5056843863 @default.
• W2002321885 creator A5076345819 @default.
• W2002321885 creator A5086618127 @default.
• W2002321885 date "2007-11-11" @default.
• W2002321885 modified "2023-10-13" @default.
• W2002321885 title "Acute allograft rejection and immunosuppression: influence on endogenous melatonin secretion" @default.
• W2002321885 cites W1964691137 @default.
• W2002321885 cites W1965805478 @default.
• W2002321885 cites W2002558311 @default.
• W2002321885 cites W2004607162 @default.
• W2002321885 cites W2015080409 @default.
• W2002321885 cites W2023650360 @default.
• W2002321885 cites W2024839583 @default.
• W2002321885 cites W2033147224 @default.
• W2002321885 cites W2038133154 @default.
• W2002321885 cites W2042793535 @default.
• W2002321885 cites W2050802147 @default.
• W2002321885 cites W2073066418 @default.
• W2002321885 cites W2073078555 @default.
• W2002321885 cites W2075058479 @default.
• W2002321885 cites W2092549653 @default.
• W2002321885 cites W2094305332 @default.
• W2002321885 cites W2107336970 @default.
• W2002321885 cites W2132163808 @default.
• W2002321885 cites W2139425168 @default.
• W2002321885 cites W2140766975 @default.
• W2002321885 cites W2155679235 @default.
• W2002321885 doi "https://doi.org/10.1111/j.1600-079x.2007.00521.x" @default.
• W2002321885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18339121" @default.
• W2002321885 hasPublicationYear "2007" @default.
• W2002321885 type Work @default.
• W2002321885 sameAs 2002321885 @default.
• W2002321885 citedByCount "9" @default.
• W2002321885 countsByYear W20023218852013 @default.
• W2002321885 countsByYear W20023218852014 @default.
• W2002321885 countsByYear W20023218852016 @default.
• W2002321885 countsByYear W20023218852020 @default.
• W2002321885 crossrefType "journal-article" @default.
• W2002321885 hasAuthorship W2002321885A5013160428 @default.
• W2002321885 hasAuthorship W2002321885A5024795724 @default.
• W2002321885 hasAuthorship W2002321885A5030268815 @default.
• W2002321885 hasAuthorship W2002321885A5031740153 @default.
• W2002321885 hasAuthorship W2002321885A5039702084 @default.
• W2002321885 hasAuthorship W2002321885A5056843863 @default.
• W2002321885 hasAuthorship W2002321885A5076345819 @default.
• W2002321885 hasAuthorship W2002321885A5086618127 @default.
• W2002321885 hasConcept C121446783 @default.
• W2002321885 hasConcept C126322002 @default.
• W2002321885 hasConcept C134018914 @default.
• W2002321885 hasConcept C150903083 @default.
• W2002321885 hasConcept C16613235 @default.
• W2002321885 hasConcept C176685330 @default.
• W2002321885 hasConcept C207001950 @default.
• W2002321885 hasConcept C2778182776 @default.
• W2002321885 hasConcept C2780252810 @default.
• W2002321885 hasConcept C2911091166 @default.
• W2002321885 hasConcept C49039625 @default.
• W2002321885 hasConcept C71924100 @default.
• W2002321885 hasConcept C86803240 @default.
• W2002321885 hasConceptScore W2002321885C121446783 @default.
• W2002321885 hasConceptScore W2002321885C126322002 @default.
• W2002321885 hasConceptScore W2002321885C134018914 @default.
• W2002321885 hasConceptScore W2002321885C150903083 @default.
• W2002321885 hasConceptScore W2002321885C16613235 @default.
• W2002321885 hasConceptScore W2002321885C176685330 @default.
• W2002321885 hasConceptScore W2002321885C207001950 @default.
• W2002321885 hasConceptScore W2002321885C2778182776 @default.
• W2002321885 hasConceptScore W2002321885C2780252810 @default.
• W2002321885 hasConceptScore W2002321885C2911091166 @default.
• W2002321885 hasConceptScore W2002321885C49039625 @default.
• W2002321885 hasConceptScore W2002321885C71924100 @default.
• W2002321885 hasConceptScore W2002321885C86803240 @default.
• W2002321885 hasIssue "3" @default.
• W2002321885 hasLocation W20023218851 @default.
• W2002321885 hasLocation W20023218852 @default.
• W2002321885 hasOpenAccess W2002321885 @default.
• W2002321885 hasPrimaryLocation W20023218851 @default.
• W2002321885 hasRelatedWork W2013943621 @default.
• W2002321885 hasRelatedWork W2035624349 @default.
• W2002321885 hasRelatedWork W2090940716 @default.
• W2002321885 hasRelatedWork W2134427402 @default.
• W2002321885 hasRelatedWork W2157939113 @default.
• W2002321885 hasRelatedWork W2313100937 @default.
• W2002321885 hasRelatedWork W2377603382 @default.
• W2002321885 hasRelatedWork W2436969829 @default.
• W2002321885 hasRelatedWork W4256234604 @default.
• W2002321885 hasRelatedWork W777362865 @default.
• W2002321885 hasVolume "44" @default.
• W2002321885 isParatext "false" @default.
• W2002321885 isRetracted "false" @default.
• W2002321885 magId "2002321885" @default.

• next