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- W2002327582 abstract "Clark and Clark using a rabbit's ear chamber in which the observation space was in direct continuity with perichondrium reported cartilage arising spontaneously in more than 40% of chambers. With a chamber of different design having a very restricted relationship to perichondrium, osteoid, that is, an unmineralized bone-like tissue, appeared in 5 of 110 animals and in two of the five there were also unrelated islands of cartilage. In one additional animal osteoid developed three months after local application of continuous pressure of minute degree. In the remaining 104 animals no cartilage or osteoid formed irrespective of the experimental usage to which the chambers were put. The results are interpreted to mean that in rabbit's ear chambers cartilage or osteoid may form from precartilaginous cells resident in or derived from perichondrium but not by metaplasia of morphologically similar connective tissue cells. If a special stimulus was necessary to activiate the precartilaginous cells then the only obvious ones were friction and pressure both of very small degree but continuously maintained for long periods." @default.
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- W2002327582 date "1963-06-01" @default.
- W2002327582 modified "2023-09-23" @default.
- W2002327582 title "Studies of cartilage and osteoid arising spontaneously and experimental attempts to induce their formation in ear chambers" @default.
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- W2002327582 doi "https://doi.org/10.1002/ar.1091460203" @default.
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