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- W2002341330 abstract "Pleurisy was induced in rats by intrapleural injection of 0.2 ml of 2% λ-carrageenin. Prostaglandin H synthase (PGHS)-2 was detected using immunoblot analysis in cells of the pleural exudate 5 h after carrageenin injection, and waned at 19 h. PGHS-1 was also detected, but was maintained at similar levels in cells before and after carrageenin injection. The level of PGHS-2 was markedly suppressed by pretreatment of rats with anti-inflammatory dose of dexamethasone (3 mg/kg, i.p.) 2 h before carrageenin injection. Furthermore, only PGHS-1, but not PGHS-2, was detected in the microsomal fraction of the lung, stomach and kidney of pleurisy-affected arid non-affected normal rats. These results suggest the involvement of PGHS-2 in the prostanoid formation in the inflammatory site" @default.
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- W2002341330 date "1994-01-01" @default.
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- W2002341330 title "<b>Detection of inducible prostaglandin H synthase-2 in cells in the exudate of rat carrageenin-induced </b><b>pleurisy </b>" @default.
- W2002341330 doi "https://doi.org/10.2220/biomedres.15.127" @default.
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