FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002357983> ?p ?o ?g. }

• W2002357983 endingPage "f5704" @default.
• W2002357983 startingPage "f5704" @default.
• W2002357983 abstract "To compare the risk of suicide, self harm, and depression in patients prescribed varenicline or bupropion with those prescribed nicotine replacement therapy.Prospective cohort study within the Clinical Practice Research Datalink.349 general practices in England.119,546 men and women aged 18 years and over who used a smoking cessation product between 1 September 2006 and 31 October 2011. There were 81,545 users of nicotine replacement products (68.2% of all users of smoking cessation medicines), 6741 bupropion (5.6%), and 31,260 varenicline (26.2%) users.Outcomes were treated depression and fatal and non-fatal self harm within three months of the first smoking cessation prescription, determined from linkage with mortality data from the Office for National Statistics (for suicide) and Hospital Episode Statistics data (for hospital admissions relating to non-fatal self harm). Hazard ratios or risk differences were estimated using Cox multivariable regression models, propensity score matching, and instrumental variable analysis using physicians' prescribing preferences as an instrument. Sensitivity analyses were performed for outcomes at six and nine months.We detected 92 cases of fatal and non-fatal self harm (326.5 events per 100,000 person years) and 1094 primary care records of treated depression (6963.3 per 100,000 person years). Cox regression analyses showed no evidence that patients prescribed varenicline had higher risks of fatal or non-fatal self harm (hazard ratio 0.88, 95% confidence interval 0.52 to 1.49) or treated depression (0.75, 0.65 to 0.87) compared with those prescribed nicotine replacement therapy. There was no evidence that patients prescribed bupropion had a higher risk of fatal or non-fatal self harm (0.83, 0.30 to 2.31) or of treated depression (0.63, 0.46 to 0.87) compared with patients prescribed nicotine replacement therapy. Similar findings were obtained using propensity score methods and instrumental variable analyses.There is no evidence of an increased risk of suicidal behaviour in patients prescribed varenicline or bupropion compared with those prescribed nicotine replacement therapy. These findings should be reassuring for users and prescribers of smoking cessation medicines." @default.
• W2002357983 created "2016-06-24" @default.
• W2002357983 creator A5013430806 @default.
• W2002357983 creator A5027462458 @default.
• W2002357983 creator A5052988941 @default.
• W2002357983 creator A5061002857 @default.
• W2002357983 creator A5065571043 @default.
• W2002357983 creator A5078250568 @default.
• W2002357983 date "2013-10-11" @default.
• W2002357983 modified "2023-10-06" @default.
• W2002357983 title "Smoking cessation treatment and risk of depression, suicide, and self harm in the Clinical Practice Research Datalink: prospective cohort study" @default.
• W2002357983 cites W14210466 @default.
• W2002357983 cites W1561272540 @default.
• W2002357983 cites W1601517327 @default.
• W2002357983 cites W1691887444 @default.
• W2002357983 cites W1734094054 @default.
• W2002357983 cites W1787139172 @default.
• W2002357983 cites W1868446464 @default.
• W2002357983 cites W187469247 @default.
• W2002357983 cites W1973270301 @default.
• W2002357983 cites W1979904772 @default.
• W2002357983 cites W1982415425 @default.
• W2002357983 cites W1985359478 @default.
• W2002357983 cites W1991296006 @default.
• W2002357983 cites W1998901719 @default.
• W2002357983 cites W2030175282 @default.
• W2002357983 cites W2041879639 @default.
• W2002357983 cites W2062546827 @default.
• W2002357983 cites W2062560594 @default.
• W2002357983 cites W2066182646 @default.
• W2002357983 cites W2071550996 @default.
• W2002357983 cites W2073225472 @default.
• W2002357983 cites W2079464036 @default.
• W2002357983 cites W2081459939 @default.
• W2002357983 cites W2083314882 @default.
• W2002357983 cites W2090606108 @default.
• W2002357983 cites W2090673567 @default.
• W2002357983 cites W2090851062 @default.
• W2002357983 cites W2101031176 @default.
• W2002357983 cites W2124758339 @default.
• W2002357983 cites W2127065386 @default.
• W2002357983 cites W2142195373 @default.
• W2002357983 cites W2146050890 @default.
• W2002357983 cites W2162715159 @default.
• W2002357983 cites W3124296889 @default.
• W2002357983 cites W3124839955 @default.
• W2002357983 cites W3144040573 @default.
• W2002357983 cites W427495572 @default.
• W2002357983 cites W2116514043 @default.
• W2002357983 doi "https://doi.org/10.1136/bmj.f5704" @default.
• W2002357983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805476" @default.
• W2002357983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24124105" @default.
• W2002357983 hasPublicationYear "2013" @default.
• W2002357983 type Work @default.
• W2002357983 sameAs 2002357983 @default.
• W2002357983 citedByCount "102" @default.
• W2002357983 countsByYear W20023579832013 @default.
• W2002357983 countsByYear W20023579832014 @default.
• W2002357983 countsByYear W20023579832015 @default.
• W2002357983 countsByYear W20023579832016 @default.
• W2002357983 countsByYear W20023579832017 @default.
• W2002357983 countsByYear W20023579832018 @default.
• W2002357983 countsByYear W20023579832019 @default.
• W2002357983 countsByYear W20023579832020 @default.
• W2002357983 countsByYear W20023579832021 @default.
• W2002357983 countsByYear W20023579832022 @default.
• W2002357983 countsByYear W20023579832023 @default.
• W2002357983 crossrefType "journal-article" @default.
• W2002357983 hasAuthorship W2002357983A5013430806 @default.
• W2002357983 hasAuthorship W2002357983A5027462458 @default.
• W2002357983 hasAuthorship W2002357983A5052988941 @default.
• W2002357983 hasAuthorship W2002357983A5061002857 @default.
• W2002357983 hasAuthorship W2002357983A5065571043 @default.
• W2002357983 hasAuthorship W2002357983A5078250568 @default.
• W2002357983 hasBestOaLocation W20023579831 @default.
• W2002357983 hasConcept C118552586 @default.
• W2002357983 hasConcept C126322002 @default.
• W2002357983 hasConcept C139719470 @default.
• W2002357983 hasConcept C142724271 @default.
• W2002357983 hasConcept C162324750 @default.
• W2002357983 hasConcept C188816634 @default.
• W2002357983 hasConcept C194828623 @default.
• W2002357983 hasConcept C201903717 @default.
• W2002357983 hasConcept C207103383 @default.
• W2002357983 hasConcept C2426938 @default.
• W2002357983 hasConcept C2776867660 @default.
• W2002357983 hasConcept C2777053506 @default.
• W2002357983 hasConcept C2777843972 @default.
• W2002357983 hasConcept C2779547902 @default.
• W2002357983 hasConcept C2779908668 @default.
• W2002357983 hasConcept C2780478649 @default.
• W2002357983 hasConcept C44249647 @default.
• W2002357983 hasConcept C50382708 @default.
• W2002357983 hasConcept C71924100 @default.
• W2002357983 hasConcept C98274493 @default.
• W2002357983 hasConceptScore W2002357983C118552586 @default.
• W2002357983 hasConceptScore W2002357983C126322002 @default.
• W2002357983 hasConceptScore W2002357983C139719470 @default.

• next