Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002363989> ?p ?o ?g. }
- W2002363989 endingPage "253" @default.
- W2002363989 startingPage "244" @default.
- W2002363989 abstract "Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid hormone receptors have been found. In this work the possible involvement of thyroid hormones in the regulation of adult neurogenesis in the granule cell layer of rat hippocampus dentate gyrus was investigated using an experimental model of adult-onset pharmacologically-induced hypothyroidism. Neurogenesis was assessed by means of the thymidine analogue 5-bromo-2′-deoxyuridine 24 h and 30 days after its last administration in order to study neural precursor proliferation and newborn cell survival, respectively. Mitotic activity of the neural precursors was not affected by thyroid hormone deficiency; on the contrary, newborn cell survival dramatically decreased under these conditions when compared with controls, leading to a lower number of immature neurons being added to the granule cell layer. Moreover, in conditions of hypothyroidism, new neurons exhibit a delay in neuronal differentiation showing a prolonged expression of the neuritogenesis-associated immature neuron marker TUC-4 and a very immature morphology. Finally, the total number and size of granule cells, and granule cell layer volume decreased in hypothyroid rats. These results suggest that thyroid hormones play a role in regulating new neuron production during adult life in dentate gyrus of rat hippocampus." @default.
- W2002363989 created "2016-06-24" @default.
- W2002363989 creator A5019925363 @default.
- W2002363989 creator A5035930587 @default.
- W2002363989 creator A5043854432 @default.
- W2002363989 creator A5056224017 @default.
- W2002363989 creator A5067536377 @default.
- W2002363989 creator A5070055302 @default.
- W2002363989 creator A5079116277 @default.
- W2002363989 creator A5091732203 @default.
- W2002363989 date "2005-01-01" @default.
- W2002363989 modified "2023-09-27" @default.
- W2002363989 title "Thyroid Hormones Affect Neurogenesis in the Dentate Gyrus of Adult Rat" @default.
- W2002363989 cites W1509319711 @default.
- W2002363989 cites W1590632482 @default.
- W2002363989 cites W1670625131 @default.
- W2002363989 cites W1963940970 @default.
- W2002363989 cites W1968761011 @default.
- W2002363989 cites W1970602849 @default.
- W2002363989 cites W1976241604 @default.
- W2002363989 cites W1980499453 @default.
- W2002363989 cites W1982850249 @default.
- W2002363989 cites W1983917472 @default.
- W2002363989 cites W1989389324 @default.
- W2002363989 cites W1989906163 @default.
- W2002363989 cites W1991665751 @default.
- W2002363989 cites W1999597664 @default.
- W2002363989 cites W1999621556 @default.
- W2002363989 cites W2000741536 @default.
- W2002363989 cites W2005790464 @default.
- W2002363989 cites W2015417034 @default.
- W2002363989 cites W2017568127 @default.
- W2002363989 cites W2024292910 @default.
- W2002363989 cites W2025604203 @default.
- W2002363989 cites W2031527419 @default.
- W2002363989 cites W2040361790 @default.
- W2002363989 cites W2042441400 @default.
- W2002363989 cites W2046006021 @default.
- W2002363989 cites W2048245477 @default.
- W2002363989 cites W2053930589 @default.
- W2002363989 cites W2060884712 @default.
- W2002363989 cites W2062684307 @default.
- W2002363989 cites W2063466545 @default.
- W2002363989 cites W2063799562 @default.
- W2002363989 cites W2064921121 @default.
- W2002363989 cites W2065616344 @default.
- W2002363989 cites W2067797384 @default.
- W2002363989 cites W2067856703 @default.
- W2002363989 cites W2076555882 @default.
- W2002363989 cites W2078946162 @default.
- W2002363989 cites W2115582509 @default.
- W2002363989 cites W2115940794 @default.
- W2002363989 cites W2116961945 @default.
- W2002363989 cites W2127878701 @default.
- W2002363989 cites W2132732672 @default.
- W2002363989 cites W2158649743 @default.
- W2002363989 cites W2159589208 @default.
- W2002363989 cites W2165224884 @default.
- W2002363989 cites W3128097275 @default.
- W2002363989 cites W2016145801 @default.
- W2002363989 cites W2412921157 @default.
- W2002363989 doi "https://doi.org/10.1159/000087648" @default.
- W2002363989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16113586" @default.
- W2002363989 hasPublicationYear "2005" @default.
- W2002363989 type Work @default.
- W2002363989 sameAs 2002363989 @default.
- W2002363989 citedByCount "123" @default.
- W2002363989 countsByYear W20023639892012 @default.
- W2002363989 countsByYear W20023639892013 @default.
- W2002363989 countsByYear W20023639892014 @default.
- W2002363989 countsByYear W20023639892015 @default.
- W2002363989 countsByYear W20023639892016 @default.
- W2002363989 countsByYear W20023639892017 @default.
- W2002363989 countsByYear W20023639892018 @default.
- W2002363989 countsByYear W20023639892019 @default.
- W2002363989 countsByYear W20023639892020 @default.
- W2002363989 countsByYear W20023639892021 @default.
- W2002363989 countsByYear W20023639892022 @default.
- W2002363989 countsByYear W20023639892023 @default.
- W2002363989 crossrefType "journal-article" @default.
- W2002363989 hasAuthorship W2002363989A5019925363 @default.
- W2002363989 hasAuthorship W2002363989A5035930587 @default.
- W2002363989 hasAuthorship W2002363989A5043854432 @default.
- W2002363989 hasAuthorship W2002363989A5056224017 @default.
- W2002363989 hasAuthorship W2002363989A5067536377 @default.
- W2002363989 hasAuthorship W2002363989A5070055302 @default.
- W2002363989 hasAuthorship W2002363989A5079116277 @default.
- W2002363989 hasAuthorship W2002363989A5091732203 @default.
- W2002363989 hasConcept C126322002 @default.
- W2002363989 hasConcept C134018914 @default.
- W2002363989 hasConcept C169760540 @default.
- W2002363989 hasConcept C2776464000 @default.
- W2002363989 hasConcept C2778794669 @default.
- W2002363989 hasConcept C2778888523 @default.
- W2002363989 hasConcept C2781161787 @default.
- W2002363989 hasConcept C4746552 @default.
- W2002363989 hasConcept C526584372 @default.
- W2002363989 hasConcept C71315377 @default.