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- W2002368949 abstract "Abstract Dextran-linked 7-deazaguanine as well as 7-deazahypoxanthine and allopurinol derivatives have been prepared by carbodiimide condensation of the 2-carboxyethyl intermediates 2c and 1c,d with N-(6-aminohexylcarbamoyl-methylated dextran T80. The dextran-linked nucleobases are degradable by endo-dextranase (EC 3.2.1.11) which was demonstrated by time-dependent viscosity measurements. Monomeric as well as polymer-linked purine analogues were tested as inhibitors of xanthine oxidase from cow's milk (EC 1.2.3.1). While the allopurinol- and 7-deazahypoxanthine derivatives (1c,d) do no longer bind to the enzyme the 7-deazaguanine derivates 2c,d are strong competitive inhibitors of xanthine oxidase even in the polymer-linked state." @default.
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- W2002368949 date "1987-08-01" @default.
- W2002368949 modified "2023-09-27" @default.
- W2002368949 title "Dextran-linked 7-deazaguanine - a polymer-bound inhibitor of xanthine oxidase" @default.
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- W2002368949 doi "https://doi.org/10.1016/0141-8130(87)90054-7" @default.
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