Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002373438> ?p ?o ?g. }
- W2002373438 endingPage "631" @default.
- W2002373438 startingPage "615" @default.
- W2002373438 abstract "Uric acid, or more correctly (at physiological pH values), its monoanion urate, is traditionally considered to be a metabolically inert end-product of purine metabolism in man, without any physiology value. However, this ubiquitous compound has proven to be selective antioxidant, capable especially of reaction with hydroxyl radicals and hypochlorous acid, itself being converted to innocuous products (allantoin, allantoate, glyoxylate, urea, oxalate). There is now evidence for such processes not only in vitro and in isolated organs, but also in the human lung in vivo. Urate may also serve as an oxidase cosubstrate for the enzyme cyclooxygenase. As shown for the coronary system, a major site of production of urates is the microvascular endothelium, and there is generally a net release of urate from the human myocardium in vivo. In isolated organ preparations, urate protects against reperfusion damage induced by activated granulocytes, cells known to produce a variety of radicals and oxidants. Intriguingly, urate prevents inactivation of endothelial enzymes (cyclooxygenase, angiotensin converting enzyme) and preserves the ability of the endothelium to mediate vascular dilatation in the face of oxidative stress, suggesting a particular relationship between the site of urate formation and the need for a biologically potent radical scavenger and antioxidant." @default.
- W2002373438 created "2016-06-24" @default.
- W2002373438 creator A5042610251 @default.
- W2002373438 date "1993-06-01" @default.
- W2002373438 modified "2023-10-11" @default.
- W2002373438 title "Towards the physiological function of uric acid" @default.
- W2002373438 cites W1559327360 @default.
- W2002373438 cites W1570634113 @default.
- W2002373438 cites W1598662907 @default.
- W2002373438 cites W1622567971 @default.
- W2002373438 cites W1832537945 @default.
- W2002373438 cites W1872893906 @default.
- W2002373438 cites W1905838994 @default.
- W2002373438 cites W1926950498 @default.
- W2002373438 cites W1963594980 @default.
- W2002373438 cites W1964510188 @default.
- W2002373438 cites W1969996465 @default.
- W2002373438 cites W1982475081 @default.
- W2002373438 cites W1985975073 @default.
- W2002373438 cites W1988799033 @default.
- W2002373438 cites W1988822992 @default.
- W2002373438 cites W1993649657 @default.
- W2002373438 cites W1993689004 @default.
- W2002373438 cites W1993773296 @default.
- W2002373438 cites W2002090096 @default.
- W2002373438 cites W2008083342 @default.
- W2002373438 cites W2011944264 @default.
- W2002373438 cites W2015649397 @default.
- W2002373438 cites W2017411482 @default.
- W2002373438 cites W2017601135 @default.
- W2002373438 cites W2018137694 @default.
- W2002373438 cites W2018151002 @default.
- W2002373438 cites W2023017689 @default.
- W2002373438 cites W2026103791 @default.
- W2002373438 cites W2030279976 @default.
- W2002373438 cites W2034228138 @default.
- W2002373438 cites W2034878415 @default.
- W2002373438 cites W2034932179 @default.
- W2002373438 cites W2036001456 @default.
- W2002373438 cites W2036244266 @default.
- W2002373438 cites W2037560533 @default.
- W2002373438 cites W2037615558 @default.
- W2002373438 cites W2038228736 @default.
- W2002373438 cites W2041393456 @default.
- W2002373438 cites W2042754674 @default.
- W2002373438 cites W2044136124 @default.
- W2002373438 cites W2047251114 @default.
- W2002373438 cites W2051337736 @default.
- W2002373438 cites W2052472954 @default.
- W2002373438 cites W2059449111 @default.
- W2002373438 cites W2062057989 @default.
- W2002373438 cites W2065311250 @default.
- W2002373438 cites W2065458293 @default.
- W2002373438 cites W2066925278 @default.
- W2002373438 cites W2069242512 @default.
- W2002373438 cites W2069563551 @default.
- W2002373438 cites W2069649968 @default.
- W2002373438 cites W2073265481 @default.
- W2002373438 cites W2076530421 @default.
- W2002373438 cites W2082395136 @default.
- W2002373438 cites W2087109791 @default.
- W2002373438 cites W2088696136 @default.
- W2002373438 cites W2091743223 @default.
- W2002373438 cites W2092460032 @default.
- W2002373438 cites W2093410158 @default.
- W2002373438 cites W2094072691 @default.
- W2002373438 cites W2096896336 @default.
- W2002373438 cites W2100752127 @default.
- W2002373438 cites W2106346650 @default.
- W2002373438 cites W2126616478 @default.
- W2002373438 cites W2142311055 @default.
- W2002373438 cites W2148151081 @default.
- W2002373438 cites W2163575194 @default.
- W2002373438 cites W2292440706 @default.
- W2002373438 cites W2316658542 @default.
- W2002373438 cites W2919203880 @default.
- W2002373438 cites W4214589643 @default.
- W2002373438 cites W4240747299 @default.
- W2002373438 doi "https://doi.org/10.1016/0891-5849(93)90143-i" @default.
- W2002373438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8325534" @default.
- W2002373438 hasPublicationYear "1993" @default.
- W2002373438 type Work @default.
- W2002373438 sameAs 2002373438 @default.
- W2002373438 citedByCount "737" @default.
- W2002373438 countsByYear W20023734382012 @default.
- W2002373438 countsByYear W20023734382013 @default.
- W2002373438 countsByYear W20023734382014 @default.
- W2002373438 countsByYear W20023734382015 @default.
- W2002373438 countsByYear W20023734382016 @default.
- W2002373438 countsByYear W20023734382017 @default.
- W2002373438 countsByYear W20023734382018 @default.
- W2002373438 countsByYear W20023734382019 @default.
- W2002373438 countsByYear W20023734382020 @default.
- W2002373438 countsByYear W20023734382021 @default.
- W2002373438 countsByYear W20023734382022 @default.
- W2002373438 countsByYear W20023734382023 @default.
- W2002373438 crossrefType "journal-article" @default.
- W2002373438 hasAuthorship W2002373438A5042610251 @default.