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- W2002382519 abstract "Recent literature suggests that sleep deprivation has a general stimulatory effect on the central serotonergic system. Herein we report that in hamsters, sleep deprivation induced by gentle handling for 3 h under dim red light at midday stimulates serotonin release in the suprachiasmatic nuclei by as much as 171%. Basal levels of 5-HT release are re-established within 1 h after cessation of treatment. Sleep deprivation also evokes phase advances of the circadian activity rhythm averaging 2 h. When sleep deprivation is undertaken in bright light, serotonin release is stimulated, but phase-shifting is greatly inhibited. It is therefore proposed that if the phase-resetting response to sleep deprivation is mediated by increased serotonin release, light inhibits the phase-resetting effect by blocking the postsynaptic or other downstream actions of serotonin." @default.
- W2002382519 created "2016-06-24" @default.
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- W2002382519 date "2000-06-01" @default.
- W2002382519 modified "2023-10-12" @default.
- W2002382519 title "Sleep deprivation stimulates serotonin release in the suprachiasmatic nucleus" @default.
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- W2002382519 doi "https://doi.org/10.1097/00001756-200006260-00024" @default.
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