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- W2002386616 abstract "As a model for interactions present in the active site of orotidine-5'-monophosphate decarboxylase (ODCase), the effect of hydrogen bonds to the carbonyl groups (O-2 and O-4) of orotic acid and its decarboxylation product was probed with ab initio calculations. We have found that the transition state/carbanion intermediate is a better proton receptor and therefore, the hydrogen bonds can be a modest source of catalysis. Comparison of the calculated data with results from site-directed mutagenesis provides some insights into the polarity of the active site." @default.
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- W2002386616 date "2004-04-01" @default.
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- W2002386616 title "Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine-5′-monophosphate decarboxylase" @default.
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- W2002386616 doi "https://doi.org/10.1016/j.bioorg.2003.11.001" @default.
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