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- W2002396752 abstract "Polylysine-dendritic sulfated cellobiose 4 was synthesized by sulfation of polylysine-dendritic cellobiose, which was prepared from cellobiose and polylysine dendrimer generation 3. The degree of sulfation was 1.85 per glucose unit (maximum 3). The molecular weights measured by GPC were M¯w=12.4×103 and M¯n=10.4×103, suggesting that the sulfated 4 had a very compact structure. The anti-HIV activity of polylysine-dendritic sulfated cellobiose 4 was assayed in vitro by the MTT method, which indicated that the EC50 = 3.2 μg/ml for the 50% inhibitory concentration of virus replication, a concentration that is as high as that of the currently clinical used AIDS drug, ddC (EC50 = 3.51 μg/ml), and low cytotoxicity (CC50 = 1000 μg/ml). The blood anticoagulant activity determined by the method of the United States Pharmacopoeia was AA = 19.4 unit/mg, as the same as that of the sulfated polysaccharides, dextran sulfate (AA = 22.9 unit/mg) and curdlan sulfate (AA = 19 unit/mg). These results suggest that the biological activities were improved by a cluster effect of the sulfated cellobiose that originated from the dendritic structure because sulfated oligosaccharides have little anti-HIV activity. The structure of polylysine-dendritic sulfated cellobiose 4 was analyzed by NMR and FT-IR measurements." @default.
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- W2002396752 date "2010-05-01" @default.
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- W2002396752 title "Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer" @default.
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- W2002396752 doi "https://doi.org/10.1016/j.carbpol.2010.01.031" @default.
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