Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002403174> ?p ?o ?g. }
- W2002403174 endingPage "217" @default.
- W2002403174 startingPage "208" @default.
- W2002403174 abstract "For studies of motor neuron function or for therapeutic purposes, novel pseudotype HIV-1-based vectors were developed that are capable of expressing transgenes in motor neurons following injection into mouse hind limb muscles. To specifically target motor neurons, glycoproteins from two rabies virus (RV) isolates, the mouse-brain adapted challenge virus 24 (CVS-24) variants, CVS-N2c and CVS-B2c were evaluated for pseudotype formation with an HIV-1-based vector. Both RV glycoproteins incorporated into vector envelopes, and both pseudotypes yielded high titers with Hek293T and cortical plate neuron cultures. Increased neuronotropism by the CVS-N2c pseudotype was not observed, suggesting that vector tropism is not solely determined by the fusogenic viral glycoprotein. Vector injection into hind limb muscles resulted in EYFP reporter gene expression in the injected muscle fibers and in spinal cord motor neurons innervating the same muscle, indicating retrograde vector transport. Intramuscular vector injections into the soleus and tibialis anterior muscles transduced 26% and 16% of all motor neurons in each motor nucleus, respectively. These transduction efficiencies may allow novel approaches to functional studies of the motor system and the treatment of neuromuscular disease." @default.
- W2002403174 created "2016-06-24" @default.
- W2002403174 creator A5022874439 @default.
- W2002403174 creator A5027413431 @default.
- W2002403174 creator A5049262794 @default.
- W2002403174 creator A5054716510 @default.
- W2002403174 creator A5076514163 @default.
- W2002403174 creator A5079122593 @default.
- W2002403174 date "2006-10-01" @default.
- W2002403174 modified "2023-09-26" @default.
- W2002403174 title "Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins" @default.
- W2002403174 cites W1513603431 @default.
- W2002403174 cites W1517217264 @default.
- W2002403174 cites W1582366896 @default.
- W2002403174 cites W1863551998 @default.
- W2002403174 cites W1975997959 @default.
- W2002403174 cites W1976696423 @default.
- W2002403174 cites W1978335031 @default.
- W2002403174 cites W1983804855 @default.
- W2002403174 cites W1985095994 @default.
- W2002403174 cites W1988878898 @default.
- W2002403174 cites W1999877750 @default.
- W2002403174 cites W2002104055 @default.
- W2002403174 cites W2003322030 @default.
- W2002403174 cites W2009031675 @default.
- W2002403174 cites W2016800164 @default.
- W2002403174 cites W2031311727 @default.
- W2002403174 cites W2035738127 @default.
- W2002403174 cites W2047088819 @default.
- W2002403174 cites W2057307199 @default.
- W2002403174 cites W2062464401 @default.
- W2002403174 cites W2065894043 @default.
- W2002403174 cites W2066282007 @default.
- W2002403174 cites W2066699285 @default.
- W2002403174 cites W2070869308 @default.
- W2002403174 cites W2073348631 @default.
- W2002403174 cites W2082694099 @default.
- W2002403174 cites W2091488679 @default.
- W2002403174 cites W2094059940 @default.
- W2002403174 cites W2096982709 @default.
- W2002403174 cites W2102157887 @default.
- W2002403174 cites W2115774463 @default.
- W2002403174 cites W2122432632 @default.
- W2002403174 cites W2123533032 @default.
- W2002403174 cites W2123779560 @default.
- W2002403174 cites W2135136739 @default.
- W2002403174 cites W2137564851 @default.
- W2002403174 cites W2141335195 @default.
- W2002403174 cites W2142797188 @default.
- W2002403174 cites W2154853638 @default.
- W2002403174 cites W2157894968 @default.
- W2002403174 cites W2332224516 @default.
- W2002403174 cites W291902505 @default.
- W2002403174 cites W4236884331 @default.
- W2002403174 doi "https://doi.org/10.1016/j.jneumeth.2006.04.011" @default.
- W2002403174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16725205" @default.
- W2002403174 hasPublicationYear "2006" @default.
- W2002403174 type Work @default.
- W2002403174 sameAs 2002403174 @default.
- W2002403174 citedByCount "47" @default.
- W2002403174 countsByYear W20024031742012 @default.
- W2002403174 countsByYear W20024031742013 @default.
- W2002403174 countsByYear W20024031742014 @default.
- W2002403174 countsByYear W20024031742015 @default.
- W2002403174 countsByYear W20024031742016 @default.
- W2002403174 countsByYear W20024031742017 @default.
- W2002403174 countsByYear W20024031742018 @default.
- W2002403174 countsByYear W20024031742019 @default.
- W2002403174 countsByYear W20024031742020 @default.
- W2002403174 countsByYear W20024031742022 @default.
- W2002403174 countsByYear W20024031742023 @default.
- W2002403174 crossrefType "journal-article" @default.
- W2002403174 hasAuthorship W2002403174A5022874439 @default.
- W2002403174 hasAuthorship W2002403174A5027413431 @default.
- W2002403174 hasAuthorship W2002403174A5049262794 @default.
- W2002403174 hasAuthorship W2002403174A5054716510 @default.
- W2002403174 hasAuthorship W2002403174A5076514163 @default.
- W2002403174 hasAuthorship W2002403174A5079122593 @default.
- W2002403174 hasConcept C104317684 @default.
- W2002403174 hasConcept C105702510 @default.
- W2002403174 hasConcept C108625454 @default.
- W2002403174 hasConcept C12554922 @default.
- W2002403174 hasConcept C15152581 @default.
- W2002403174 hasConcept C153911025 @default.
- W2002403174 hasConcept C159047783 @default.
- W2002403174 hasConcept C169760540 @default.
- W2002403174 hasConcept C2522874641 @default.
- W2002403174 hasConcept C2776379899 @default.
- W2002403174 hasConcept C2776752467 @default.
- W2002403174 hasConcept C2776849203 @default.
- W2002403174 hasConcept C2777961786 @default.
- W2002403174 hasConcept C2779959927 @default.
- W2002403174 hasConcept C2780775167 @default.
- W2002403174 hasConcept C32470452 @default.
- W2002403174 hasConcept C33602714 @default.
- W2002403174 hasConcept C35693153 @default.
- W2002403174 hasConcept C40767141 @default.
- W2002403174 hasConcept C55493867 @default.