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- W2002413587 abstract "1. Changes in the electrically-excitable and mechanical responsiveness of Schistocerca and Periplaneta muscle fibres occur following treatment with ryanodine concentrations as low as 10−9 M. 2. The resting resistance, length constant and time constant are all increased initially. 3. In many fibres the normal graded responses are converted to all-or-none responses. 4. The excitability of the muscle fibre membrane is increased and repetitive spikes appear. More rarely spontaneous spikes arise neurogenically. 5. These changes of responsiveness are described in terms of diminished potassium conductance. 6. During the later stages of poisoning the changes are reversed. 7. With repeated indirect stimulation both “slow” and “fast” mechanical responses are inhibited in ryanodine-saline. 8. With intermittent stimulation only the mechanical responses are first potentiated and then inhibited." @default.
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- W2002413587 date "1962-07-01" @default.
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- W2002413587 title "The action of the alkaloid ryanodine on insect skeletal muscle" @default.
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- W2002413587 doi "https://doi.org/10.1016/0010-406x(62)90077-4" @default.
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