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- W2002423928 endingPage "382" @default.
- W2002423928 startingPage "370" @default.
- W2002423928 abstract "Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized LDL, growth factors, pro-inflammatory cytokines and fluid shear stress converge upon and activate lactosylceramide synthase to generate LacCer. In turn, LacCer activates an oxygen-sensitive signaling pathway involving superoxides, nitric oxide, p21 Ras GTP loading, kinase cascade, PI3kinase/Akt activation, nuclear factor up-regulation ultimately contributing to phenotypic changes such as cell proliferation, adhesion, migration and angiogenesis. Since dys-regulation of such phenotypic changes constitute a hallmark in several diseases of the cardiovascular system, proliferative disorders such as cancer, polycystic kidney disease and inflammatory diseases, LacCer synthase and LacCer provide novel targets for the development of therapeutics aimed at these health conditions." @default.
- W2002423928 created "2016-06-24" @default.
- W2002423928 creator A5000104019 @default.
- W2002423928 creator A5024931198 @default.
- W2002423928 date "2008-03-01" @default.
- W2002423928 modified "2023-10-16" @default.
- W2002423928 title "The Yin and Yang of lactosylceramide metabolism: Implications in cell function" @default.
- W2002423928 cites W1508039723 @default.
- W2002423928 cites W1514486811 @default.
- W2002423928 cites W1521220661 @default.
- W2002423928 cites W1532731856 @default.
- W2002423928 cites W1552785739 @default.
- W2002423928 cites W1576578649 @default.
- W2002423928 cites W1578167606 @default.
- W2002423928 cites W1581769797 @default.
- W2002423928 cites W1583865009 @default.
- W2002423928 cites W1587638607 @default.
- W2002423928 cites W1603566729 @default.
- W2002423928 cites W1608750708 @default.
- W2002423928 cites W1628167280 @default.
- W2002423928 cites W166003802 @default.
- W2002423928 cites W1750381543 @default.
- W2002423928 cites W1826433977 @default.
- W2002423928 cites W1859884118 @default.
- W2002423928 cites W1894060385 @default.
- W2002423928 cites W1935495182 @default.
- W2002423928 cites W1941605537 @default.
- W2002423928 cites W1968027634 @default.
- W2002423928 cites W1970674113 @default.
- W2002423928 cites W1972049323 @default.
- W2002423928 cites W1973406875 @default.
- W2002423928 cites W1978768249 @default.
- W2002423928 cites W1980129981 @default.
- W2002423928 cites W1982704287 @default.
- W2002423928 cites W1985199555 @default.
- W2002423928 cites W1987162287 @default.
- W2002423928 cites W1987759495 @default.
- W2002423928 cites W1990163397 @default.
- W2002423928 cites W1993696327 @default.
- W2002423928 cites W1994266173 @default.
- W2002423928 cites W1996682859 @default.
- W2002423928 cites W1998728674 @default.
- W2002423928 cites W1999842850 @default.
- W2002423928 cites W2000000541 @default.
- W2002423928 cites W2000334999 @default.
- W2002423928 cites W2005343690 @default.
- W2002423928 cites W2006133972 @default.
- W2002423928 cites W2008078894 @default.
- W2002423928 cites W2008178647 @default.
- W2002423928 cites W2009746140 @default.
- W2002423928 cites W2018323373 @default.
- W2002423928 cites W2020209752 @default.
- W2002423928 cites W2021505229 @default.
- W2002423928 cites W2023851206 @default.
- W2002423928 cites W2026507072 @default.
- W2002423928 cites W2028376423 @default.
- W2002423928 cites W2034052978 @default.
- W2002423928 cites W2034520446 @default.
- W2002423928 cites W2036092831 @default.
- W2002423928 cites W2041363013 @default.
- W2002423928 cites W2044098638 @default.
- W2002423928 cites W2052094618 @default.
- W2002423928 cites W2052848320 @default.
- W2002423928 cites W2054655880 @default.
- W2002423928 cites W2055329245 @default.
- W2002423928 cites W2062066327 @default.
- W2002423928 cites W2064633417 @default.
- W2002423928 cites W2066963386 @default.
- W2002423928 cites W2068384505 @default.
- W2002423928 cites W2073667518 @default.
- W2002423928 cites W2076812453 @default.
- W2002423928 cites W2077400632 @default.
- W2002423928 cites W2077639939 @default.
- W2002423928 cites W2079463341 @default.
- W2002423928 cites W2079728938 @default.
- W2002423928 cites W2080220449 @default.
- W2002423928 cites W2081381108 @default.
- W2002423928 cites W2084201369 @default.
- W2002423928 cites W2085937559 @default.
- W2002423928 cites W2086176714 @default.
- W2002423928 cites W2088844754 @default.
- W2002423928 cites W2089799567 @default.
- W2002423928 cites W2090047228 @default.
- W2002423928 cites W2093317801 @default.
- W2002423928 cites W2096367197 @default.
- W2002423928 cites W2111452373 @default.
- W2002423928 cites W2112071381 @default.
- W2002423928 cites W2113237092 @default.
- W2002423928 cites W2123224737 @default.
- W2002423928 cites W2125232915 @default.
- W2002423928 cites W2129232972 @default.
- W2002423928 cites W2132076177 @default.
- W2002423928 cites W2135633069 @default.
- W2002423928 cites W2138976254 @default.
- W2002423928 cites W2142290822 @default.
- W2002423928 cites W2142501903 @default.
- W2002423928 cites W2142699394 @default.
- W2002423928 cites W2152443075 @default.