FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002425246> ?p ?o ?g. }

• W2002425246 endingPage "1547" @default.
• W2002425246 startingPage "1533" @default.
• W2002425246 abstract "Fus1 has been established as mitochondrial tumor suppressor, immunomodulator, and antioxidant protein, but molecular mechanism of these activities remained to be identified. Based on putative calcium-binding and myristoyl-binding domains that we identified in Fus1, we explored our hypothesis that Fus1 regulates mitochondrial calcium handling and calcium-coupled processes.Fus1 loss resulted in reduced rate of mitochondrial calcium uptake in calcium-loaded epithelial cells, splenocytes, and activated CD4(+) T cells. The reduced rate of mitochondrial calcium uptake in Fus1-deficient cells correlated with cytosolic calcium increase and dysregulation of calcium-coupled mitochondrial parameters, such as reactive oxygen species production, ΔμH(+), mitochondrial permeability transition pore opening, and GSH content. Inhibition of calcium efflux via mitochondria, Na(+)/Ca(2+) exchanger significantly improved the mitochondrial calcium uptake in Fus1(-/-) cells. Ex vivo analysis of activated CD4(+) T cells showed Fus1-dependent changes in calcium-regulated processes, such as surface expression of CD4 and PD1/PD-L1, proliferation, and Th polarization. Fus1(-/-) T cells showed increased basal expression of calcium-dependent NF-κB and NFAT targets but were unable to fully activate these pathways after stimulation.Our results establish Fus1 as one of the few identified regulators of mitochondrial calcium handling. Our data support the idea that alterations in mitochondrial calcium dynamics could lead to the disruption of metabolic coupling in mitochondria that, in turn, may result in multiple cellular and systemic abnormalities.Our findings suggest that Fus1 achieves its protective role in inflammation, autoimmunity, and cancer via the regulation of mitochondrial calcium and calcium-coupled parameters." @default.
• W2002425246 created "2016-06-24" @default.
• W2002425246 creator A5001660012 @default.
• W2002425246 creator A5019557489 @default.
• W2002425246 creator A5040597705 @default.
• W2002425246 creator A5052011893 @default.
• W2002425246 creator A5057214819 @default.
• W2002425246 creator A5069589993 @default.
• W2002425246 date "2014-04-01" @default.
• W2002425246 modified "2023-09-27" @default.
• W2002425246 title "Fus1/Tusc2 Is a Novel Regulator of Mitochondrial Calcium Handling, Ca²⁺-Coupled Mitochondrial Processes, and Ca²⁺-Dependent NFAT and NF-κB Pathways in CD4⁺T Cells" @default.
• W2002425246 cites W1491042842 @default.
• W2002425246 cites W1500939659 @default.
• W2002425246 cites W1518080160 @default.
• W2002425246 cites W1607859230 @default.
• W2002425246 cites W1670420367 @default.
• W2002425246 cites W1871243464 @default.
• W2002425246 cites W1919647167 @default.
• W2002425246 cites W1943570680 @default.
• W2002425246 cites W1950726686 @default.
• W2002425246 cites W1970610775 @default.
• W2002425246 cites W1972718661 @default.
• W2002425246 cites W1973807205 @default.
• W2002425246 cites W1975038690 @default.
• W2002425246 cites W1977244334 @default.
• W2002425246 cites W1980959570 @default.
• W2002425246 cites W1985106225 @default.
• W2002425246 cites W1986213783 @default.
• W2002425246 cites W1990998879 @default.
• W2002425246 cites W1991055482 @default.
• W2002425246 cites W1992868369 @default.
• W2002425246 cites W1993851979 @default.
• W2002425246 cites W2000293859 @default.
• W2002425246 cites W2002791298 @default.
• W2002425246 cites W2003579048 @default.
• W2002425246 cites W2018019380 @default.
• W2002425246 cites W2022425508 @default.
• W2002425246 cites W2023283007 @default.
• W2002425246 cites W2028092741 @default.
• W2002425246 cites W2031752845 @default.
• W2002425246 cites W2033687652 @default.
• W2002425246 cites W2037600884 @default.
• W2002425246 cites W2038468721 @default.
• W2002425246 cites W2041748354 @default.
• W2002425246 cites W2044761366 @default.
• W2002425246 cites W2046490162 @default.
• W2002425246 cites W2049388490 @default.
• W2002425246 cites W2051861425 @default.
• W2002425246 cites W2054678965 @default.
• W2002425246 cites W2063772445 @default.
• W2002425246 cites W2066361434 @default.
• W2002425246 cites W2067841051 @default.
• W2002425246 cites W2068048197 @default.
• W2002425246 cites W2070204898 @default.
• W2002425246 cites W2071507812 @default.
• W2002425246 cites W2072605361 @default.
• W2002425246 cites W2080376295 @default.
• W2002425246 cites W2086276885 @default.
• W2002425246 cites W2089926295 @default.
• W2002425246 cites W2092277664 @default.
• W2002425246 cites W2094418791 @default.
• W2002425246 cites W2105043890 @default.
• W2002425246 cites W2106229831 @default.
• W2002425246 cites W2108328574 @default.
• W2002425246 cites W2115788076 @default.
• W2002425246 cites W2121105894 @default.
• W2002425246 cites W2123953006 @default.
• W2002425246 cites W2126337135 @default.
• W2002425246 cites W2126584062 @default.
• W2002425246 cites W2133926860 @default.
• W2002425246 cites W2134506141 @default.
• W2002425246 cites W2153838854 @default.
• W2002425246 cites W2157973267 @default.
• W2002425246 cites W2161889530 @default.
• W2002425246 cites W2162633290 @default.
• W2002425246 cites W2164156889 @default.
• W2002425246 cites W2166070510 @default.
• W2002425246 cites W2170694961 @default.
• W2002425246 cites W2971700467 @default.
• W2002425246 cites W2088729275 @default.
• W2002425246 doi "https://doi.org/10.1089/ars.2013.5437" @default.
• W2002425246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3942676" @default.
• W2002425246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24328503" @default.
• W2002425246 hasPublicationYear "2014" @default.
• W2002425246 type Work @default.
• W2002425246 sameAs 2002425246 @default.
• W2002425246 citedByCount "30" @default.
• W2002425246 countsByYear W20024252462014 @default.
• W2002425246 countsByYear W20024252462015 @default.
• W2002425246 countsByYear W20024252462016 @default.
• W2002425246 countsByYear W20024252462017 @default.
• W2002425246 countsByYear W20024252462018 @default.
• W2002425246 countsByYear W20024252462019 @default.
• W2002425246 countsByYear W20024252462021 @default.
• W2002425246 countsByYear W20024252462022 @default.
• W2002425246 countsByYear W20024252462023 @default.
• W2002425246 crossrefType "journal-article" @default.
• W2002425246 hasAuthorship W2002425246A5001660012 @default.

• next