Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002430259> ?p ?o ?g. }
- W2002430259 endingPage "1154" @default.
- W2002430259 startingPage "1146" @default.
- W2002430259 abstract "G protein-coupled receptors (GPCRs) play critical roles in cellular signal transduction and are important targets for therapeutics. Although these receptors have been intensely studied for quite some time, our understanding about their mechanism of action is still incomplete. GPCR activity has traditionally been viewed within the context of two-state models where the receptor is in equilibrium between a single inactive state and a single active state. This framework is too simple and restrictive to accommodate more recent observations made on these receptors, which instead point to a situation where the receptor can adopt several different active conformational substates with distinct functional effects. Structural and functional evidence for this emerging view is presented in this review. Implications of this emerging view in rationalizing diseased states and in drug discovery are also discussed." @default.
- W2002430259 created "2016-06-24" @default.
- W2002430259 creator A5046466620 @default.
- W2002430259 date "2012-03-01" @default.
- W2002430259 modified "2023-10-18" @default.
- W2002430259 title "Ensemble of G Protein-Coupled Receptor Active States" @default.
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