Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002433690> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2002433690 endingPage "8563" @default.
- W2002433690 startingPage "8552" @default.
- W2002433690 abstract "The a-factor of Saccharomyces cerevisiae is a dodecapeptide pheromone (YIIKGVFWDPAC(Farnesyl)-OCH(3), 1), in which post-translational modification with a farnesyl isoprenoid and carboxymethyl group is required for full biological activity. This peptide has been used as a model system to explore the biological function of the farnesylcysteine moiety, which is found on and required for the biological activity of many key mammalian proteins. The objective of this particular study was the determination of the biological effect of double bond isomerization of the natural E, E-farnesyl moiety on the biological activity of the a-factor. A unified, stereoselective synthetic route to the three geometric isomers of E,E-farnesol (12, 13, and 14) has been developed. The key feature of this synthesis is the ability to control the stereochemistry of triflation of the beta-ketoester 22 to give either 23 or 25. The three farnesol isomers were converted to the corresponding isomeric a-factors (9, 10 and 11) via a modified version of a previously utilized synthetic route. Biological evaluation of these peptides indicates that, surprisingly, all three possess nearly equivalent activity to the natural a-factor bearing the E,E-farnesyl moiety." @default.
- W2002433690 created "2016-06-24" @default.
- W2002433690 creator A5042774299 @default.
- W2002433690 creator A5044184936 @default.
- W2002433690 creator A5059626751 @default.
- W2002433690 creator A5070030950 @default.
- W2002433690 creator A5071222644 @default.
- W2002433690 date "2000-11-16" @default.
- W2002433690 modified "2023-10-17" @default.
- W2002433690 title "Synthesis and Biological Evaluation of the Geometric Farnesylated Analogues of the a-Factor Mating Peptide of <i>Saccharomyces </i><i>c</i><i>erevisiae</i>" @default.
- W2002433690 cites W1503782989 @default.
- W2002433690 cites W1937262478 @default.
- W2002433690 cites W1978088045 @default.
- W2002433690 cites W1980300128 @default.
- W2002433690 cites W1985839819 @default.
- W2002433690 cites W1989171805 @default.
- W2002433690 cites W1991402029 @default.
- W2002433690 cites W1996680126 @default.
- W2002433690 cites W2004377722 @default.
- W2002433690 cites W2006090558 @default.
- W2002433690 cites W2016033634 @default.
- W2002433690 cites W2017184139 @default.
- W2002433690 cites W2043805535 @default.
- W2002433690 cites W2059373941 @default.
- W2002433690 cites W2061598184 @default.
- W2002433690 cites W2078473016 @default.
- W2002433690 cites W2079195006 @default.
- W2002433690 cites W2079730499 @default.
- W2002433690 cites W2085672600 @default.
- W2002433690 cites W2090051807 @default.
- W2002433690 cites W2099192887 @default.
- W2002433690 cites W2101301592 @default.
- W2002433690 cites W2105471450 @default.
- W2002433690 cites W2112996671 @default.
- W2002433690 cites W2123685734 @default.
- W2002433690 cites W2168555942 @default.
- W2002433690 cites W2176744910 @default.
- W2002433690 cites W2345024092 @default.
- W2002433690 cites W2949716463 @default.
- W2002433690 cites W2951253440 @default.
- W2002433690 doi "https://doi.org/10.1021/jo000942m" @default.
- W2002433690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11112575" @default.
- W2002433690 hasPublicationYear "2000" @default.
- W2002433690 type Work @default.
- W2002433690 sameAs 2002433690 @default.
- W2002433690 citedByCount "28" @default.
- W2002433690 countsByYear W20024336902012 @default.
- W2002433690 countsByYear W20024336902013 @default.
- W2002433690 countsByYear W20024336902015 @default.
- W2002433690 countsByYear W20024336902016 @default.
- W2002433690 countsByYear W20024336902017 @default.
- W2002433690 countsByYear W20024336902023 @default.
- W2002433690 crossrefType "journal-article" @default.
- W2002433690 hasAuthorship W2002433690A5042774299 @default.
- W2002433690 hasAuthorship W2002433690A5044184936 @default.
- W2002433690 hasAuthorship W2002433690A5059626751 @default.
- W2002433690 hasAuthorship W2002433690A5070030950 @default.
- W2002433690 hasAuthorship W2002433690A5071222644 @default.
- W2002433690 hasConcept C116073593 @default.
- W2002433690 hasConcept C185592680 @default.
- W2002433690 hasConcept C202751555 @default.
- W2002433690 hasConcept C2776568683 @default.
- W2002433690 hasConcept C2777576037 @default.
- W2002433690 hasConcept C2779222958 @default.
- W2002433690 hasConcept C2779247237 @default.
- W2002433690 hasConcept C2779281246 @default.
- W2002433690 hasConcept C55493867 @default.
- W2002433690 hasConcept C71240020 @default.
- W2002433690 hasConceptScore W2002433690C116073593 @default.
- W2002433690 hasConceptScore W2002433690C185592680 @default.
- W2002433690 hasConceptScore W2002433690C202751555 @default.
- W2002433690 hasConceptScore W2002433690C2776568683 @default.
- W2002433690 hasConceptScore W2002433690C2777576037 @default.
- W2002433690 hasConceptScore W2002433690C2779222958 @default.
- W2002433690 hasConceptScore W2002433690C2779247237 @default.
- W2002433690 hasConceptScore W2002433690C2779281246 @default.
- W2002433690 hasConceptScore W2002433690C55493867 @default.
- W2002433690 hasConceptScore W2002433690C71240020 @default.
- W2002433690 hasIssue "25" @default.
- W2002433690 hasLocation W20024336901 @default.
- W2002433690 hasLocation W20024336902 @default.
- W2002433690 hasOpenAccess W2002433690 @default.
- W2002433690 hasPrimaryLocation W20024336901 @default.
- W2002433690 hasRelatedWork W1980936162 @default.
- W2002433690 hasRelatedWork W2009134735 @default.
- W2002433690 hasRelatedWork W2091334120 @default.
- W2002433690 hasRelatedWork W2110843437 @default.
- W2002433690 hasRelatedWork W2140056398 @default.
- W2002433690 hasRelatedWork W2144120004 @default.
- W2002433690 hasRelatedWork W2297295742 @default.
- W2002433690 hasRelatedWork W2561802042 @default.
- W2002433690 hasRelatedWork W2625766277 @default.
- W2002433690 hasRelatedWork W4213379265 @default.
- W2002433690 hasVolume "65" @default.
- W2002433690 isParatext "false" @default.
- W2002433690 isRetracted "false" @default.
- W2002433690 magId "2002433690" @default.
- W2002433690 workType "article" @default.