FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002437700> ?p ?o ?g. }

• W2002437700 endingPage "165" @default.
• W2002437700 startingPage "136" @default.
• W2002437700 abstract "Renal cell carcinoma (RCC), although occurring less frequently than prostate and bladder cancer, is actually the most malignant urologic disease, killing >35% of affected patients. Therefore, investigation of the nature of premalignant lesions of the kidney is a relevant issue. Following the most recent histological classification RCC can be subdivided into four categories: conventional RCC; papillary RCC; chromophobe RCC; and collecting duct carcinoma. In contrast to many genitourinary malignancies, premalignant alterations in the kidney are scarcely described. Intratubular epithelial dysplasia has been recognized as the most common precursor of RCC. In analogy to prostatic intraepithelial neoplasia (PIN), the premalignant lesions of the kidney are described as high or low-grade renal intratubular neoplasia. In contrast, precancerous lesions have been described as part of the von Hippel-Lindau syndrome (VHL) where the evolution from a simple cyst to an atypical cyst with epithelial hyperplasia to cystic or solid conventional-type RCC is well documented. Finally, in the genesis of papillary RCC an adenoma-carcinoma sequence has been recognized with specific genetic changes. There are no data on the epidemiology of premalignant lesions of the kidney, but research into the etiology of RCC has been extended substantially. Familial and genetic factors are well documented in VHL disease, in hereditary papillary RCC, in the tuberous sclerosis complex and in familial RCC. Cigarette smoking and obesity are established risk factors for RCC. Hypertension or its medication has also been associated with an increased risk. Among dietary factors an inverse relation between risk and consumption of vegetables and fruit has been found. Occupational exposure to substances such as asbestos and solvents has been linked to an increased risk of RCC. Specific RCC variants have distinctive chromosome alterations and several genes have been implicated in the development of RCC. Loss of material from the 3p chromosome characterizes conventional RCC and the deletion of the VHL suppressor gene plays an important role in the genesis of this RCC variant. In contrast, numerical changes with trisomy of chromosomes 7 and 17 and loss of the sex chromosome are typical changes in papillary tumors, whereas papillary RCC have additional trisomies. Chromophobe RCC is characterized by loss of chromosomes with a combination of monosomies. Less consistent genetic alterations are associated with collecting duct carcinoma. The traditional treatment of RCC is surgery by radical or partial nephrectomy. The latter approach carries a risk of tumor recurrence as a result of unrecognized satellite lesions or premalignant lesions that might have been present at the time of surgery. However, the reported recurrence rates after partial nephrectomy are <1% and therefore the possible presence of premalignant disease does not alter the actual treatment strategy advocated. Although multifocality and bilateral occurrence of RCC are much more likely in cases of papillary RCC, biopsy of the renal remnant or contralateral kidney is not justified even in patients with this tumor type. Conversely, patients with RIN in a partial or radical nephrectomy specimen or in a renal biopsy taken for whatever reason should be subjected to closer follow-up with regularly repeated ultrasound. When an effective chemopreventive regimen becomes available it might be useful for patients with an inherited risk of RCC as well as in those who are at risk of tumor recurrence after intervention. Mass screening with the purpose of detecting RCC at its earliest stage is not recommended at the present time, but screening focused on certain risk groups can be advocated. Further research is needed to identify avoidable risks, develop effective chemoprevention and recognize patients at risk." @default.
• W2002437700 created "2016-06-24" @default.
• W2002437700 creator A5013732253 @default.
• W2002437700 creator A5015867803 @default.
• W2002437700 creator A5018427648 @default.
• W2002437700 creator A5024626836 @default.
• W2002437700 creator A5026265347 @default.
• W2002437700 creator A5042550974 @default.
• W2002437700 creator A5049779157 @default.
• W2002437700 creator A5060545410 @default.
• W2002437700 creator A5060616205 @default.
• W2002437700 creator A5062519984 @default.
• W2002437700 creator A5067200658 @default.
• W2002437700 creator A5067620976 @default.
• W2002437700 creator A5070309168 @default.
• W2002437700 creator A5082719104 @default.
• W2002437700 creator A5082828068 @default.
• W2002437700 creator A5083842964 @default.
• W2002437700 date "2000-01-01" @default.
• W2002437700 modified "2023-10-15" @default.
• W2002437700 title "Precancerous Lesions in the Kidney" @default.
• W2002437700 cites W1450544773 @default.
• W2002437700 cites W149910344 @default.
• W2002437700 cites W1753238115 @default.
• W2002437700 cites W1834604572 @default.
• W2002437700 cites W1865590754 @default.
• W2002437700 cites W1896159598 @default.
• W2002437700 cites W1940956811 @default.
• W2002437700 cites W1963539463 @default.
• W2002437700 cites W1968361060 @default.
• W2002437700 cites W1969963339 @default.
• W2002437700 cites W1970901330 @default.
• W2002437700 cites W1972475820 @default.
• W2002437700 cites W1974453586 @default.
• W2002437700 cites W1976184018 @default.
• W2002437700 cites W1980680559 @default.
• W2002437700 cites W1980689817 @default.
• W2002437700 cites W1980754624 @default.
• W2002437700 cites W1981329738 @default.
• W2002437700 cites W1984524138 @default.
• W2002437700 cites W1986767326 @default.
• W2002437700 cites W1987380247 @default.
• W2002437700 cites W1989456474 @default.
• W2002437700 cites W1996715439 @default.
• W2002437700 cites W2000637844 @default.
• W2002437700 cites W2004273765 @default.
• W2002437700 cites W2005294445 @default.
• W2002437700 cites W2006498512 @default.
• W2002437700 cites W2006519253 @default.
• W2002437700 cites W2006682466 @default.
• W2002437700 cites W2007691463 @default.
• W2002437700 cites W2008275716 @default.
• W2002437700 cites W2010160635 @default.
• W2002437700 cites W2010620515 @default.
• W2002437700 cites W2011345676 @default.
• W2002437700 cites W2011701047 @default.
• W2002437700 cites W2011758103 @default.
• W2002437700 cites W2012766683 @default.
• W2002437700 cites W2013058594 @default.
• W2002437700 cites W2017665143 @default.
• W2002437700 cites W2019282640 @default.
• W2002437700 cites W2019573100 @default.
• W2002437700 cites W2021486906 @default.
• W2002437700 cites W2021559955 @default.
• W2002437700 cites W2022873097 @default.
• W2002437700 cites W2030507641 @default.
• W2002437700 cites W2032400327 @default.
• W2002437700 cites W2033214798 @default.
• W2002437700 cites W2033803003 @default.
• W2002437700 cites W2036006573 @default.
• W2002437700 cites W2036964953 @default.
• W2002437700 cites W2037925604 @default.
• W2002437700 cites W2038154508 @default.
• W2002437700 cites W2039496940 @default.
• W2002437700 cites W2039948400 @default.
• W2002437700 cites W2041889730 @default.
• W2002437700 cites W2043110501 @default.
• W2002437700 cites W2045674269 @default.
• W2002437700 cites W2050620710 @default.
• W2002437700 cites W2053817696 @default.
• W2002437700 cites W2053944277 @default.
• W2002437700 cites W2055915689 @default.
• W2002437700 cites W2056340515 @default.
• W2002437700 cites W2057325536 @default.
• W2002437700 cites W2057462098 @default.
• W2002437700 cites W2058980273 @default.
• W2002437700 cites W2061805255 @default.
• W2002437700 cites W2063041535 @default.
• W2002437700 cites W2063167079 @default.
• W2002437700 cites W2064291467 @default.
• W2002437700 cites W2064970264 @default.
• W2002437700 cites W2068555261 @default.
• W2002437700 cites W2069899769 @default.
• W2002437700 cites W2071370251 @default.
• W2002437700 cites W2077042713 @default.
• W2002437700 cites W2079105156 @default.
• W2002437700 cites W2083664848 @default.
• W2002437700 cites W2084801227 @default.

• next