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• W2002441749 abstract "Organophosphorus (OP) compounds include a broad group of toxic chemicals such as insecticides, chemical warfare agents and antiwear agents. The liver cytochromes P450 bioactivate many OPs to potent inhibitors of serine hydrolases. Cholinesterases were the first OP targets discovered and are the most studied. They are used to monitor human exposures to OP compounds. However, the assay that is currently used has limitations. The mechanism of action of OP compounds is the inhibition of serine hydrolases by covalently modifying their active-site serine. After structural rearrangement, the complex OP inhibitor-enzyme is irreversible and will remain in circulation until the modified enzyme is degraded. Mass spectrometry is a sensitive technology for analyzing protein modifications, such as OP-adducted enzymes. These analyses also provide some information about the nature of the OP adduct. Our aim is to develop high-throughput protocols for monitoring OP exposures using mass spectrometry." @default.
• W2002441749 created "2016-06-24" @default.
• W2002441749 creator A5041551879 @default.
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• W2002441749 date "2013-03-01" @default.
• W2002441749 modified "2023-10-07" @default.
• W2002441749 title "Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures" @default.
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• W2002441749 doi "https://doi.org/10.1016/j.cbi.2012.10.019" @default.
• W2002441749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4108156" @default.
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