FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002452401> ?p ?o ?g. }

• W2002452401 endingPage "119" @default.
• W2002452401 startingPage "119" @default.
• W2002452401 abstract "Treating resistant hypertension: role of renal denervation Daniel Urban, Sebastian Ewen, Christian Ukena, Dominik Linz, Michael Böhm, Felix Mahfoud Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital of Saarland, Homburg, Saarland, Germany Abstract: Arterial hypertension is the most prevalent risk factor associated with increased cardiovascular morbidity and mortality. Although pharmacological treatment is generally well tolerated, 5%–20% of patients with hypertension are resistant to medical therapy, which is defined as blood pressure above goal (>140/90 mmHg in general; >130–139/80–85 mmHg in patients with diabetes mellitus; >130/80 mmHg in patients with chronic kidney disease) despite treatment with ≥3 antihypertensive drugs of different classes, including a diuretic, at optimal doses. These patients are at significantly higher risk for cardiovascular events, in particular stroke, myocardial infarction, and heart failure, as compared with patients with nonresistant hypertension. The etiology of resistant hypertension is multifactorial and a number of risk factors have been identified. In addition, resistant hypertension might be due to secondary causes such as primary aldosteronism, chronic kidney disease, renal artery stenosis, or obstructive sleep apnea. To identify patients with resistant hypertension, the following must be excluded: pseudo-resistance, which might be due to nonadherence to medical treatment; white-coat effect; and inaccurate measurement technique. Activation of the sympathetic nervous system contributes to the development and maintenance of hypertension by increasing renal renin release, decreasing renal blood flow, and enhancing tubular sodium retention. Catheter-based renal denervation (RDN) is a novel technique specifically targeting renal sympathetic nerves. Clinical trials have demonstrated that RDN significantly reduces blood pressure in patients with resistant hypertension. Experimental studies and small clinical studies indicate that RDN might also have beneficial effects in other diseases and comorbidities, characterized by increased sympathetic activity, such as left ventricular hypertrophy, heart failure, metabolic syndrome and hyperinsulinemia, atrial fibrillation, obstructive sleep apnea, and chronic kidney disease. Further controlled studies are required to investigate the role of RDN beyond blood pressure control. Keywords: resistant hypertension, secondary hypertension, sympathetic nervous system, renal denervation, symplicity" @default.
• W2002452401 created "2016-06-24" @default.
• W2002452401 creator A5028556274 @default.
• W2002452401 creator A5029674394 @default.
• W2002452401 creator A5050373267 @default.
• W2002452401 creator A5070009979 @default.
• W2002452401 creator A5073388924 @default.
• W2002452401 creator A5075102218 @default.
• W2002452401 date "2013-09-01" @default.
• W2002452401 modified "2023-09-25" @default.
• W2002452401 title "Treating resistant hypertension: role of renal denervation" @default.
• W2002452401 cites W1583834060 @default.
• W2002452401 cites W1966430255 @default.
• W2002452401 cites W1972590325 @default.
• W2002452401 cites W1977132449 @default.
• W2002452401 cites W1980533403 @default.
• W2002452401 cites W1988122810 @default.
• W2002452401 cites W1993599355 @default.
• W2002452401 cites W2001261464 @default.
• W2002452401 cites W2016518103 @default.
• W2002452401 cites W2016964820 @default.
• W2002452401 cites W2017767820 @default.
• W2002452401 cites W2019975440 @default.
• W2002452401 cites W2022932618 @default.
• W2002452401 cites W2034163551 @default.
• W2002452401 cites W2035597332 @default.
• W2002452401 cites W2040380685 @default.
• W2002452401 cites W2050817452 @default.
• W2002452401 cites W2055834296 @default.
• W2002452401 cites W2065121034 @default.
• W2002452401 cites W2066349496 @default.
• W2002452401 cites W2068236391 @default.
• W2002452401 cites W2076609670 @default.
• W2002452401 cites W2080450195 @default.
• W2002452401 cites W2082072583 @default.
• W2002452401 cites W2085181031 @default.
• W2002452401 cites W2087763591 @default.
• W2002452401 cites W2089259727 @default.
• W2002452401 cites W2090636734 @default.
• W2002452401 cites W2092480962 @default.
• W2002452401 cites W2096346609 @default.
• W2002452401 cites W2099562899 @default.
• W2002452401 cites W2099897414 @default.
• W2002452401 cites W2100509598 @default.
• W2002452401 cites W2102578812 @default.
• W2002452401 cites W2113750355 @default.
• W2002452401 cites W2114127328 @default.
• W2002452401 cites W2114600946 @default.
• W2002452401 cites W2115461708 @default.
• W2002452401 cites W2119080429 @default.
• W2002452401 cites W2122826224 @default.
• W2002452401 cites W2123890702 @default.
• W2002452401 cites W2128791637 @default.
• W2002452401 cites W2129695314 @default.
• W2002452401 cites W2129991662 @default.
• W2002452401 cites W2135447024 @default.
• W2002452401 cites W2145524929 @default.
• W2002452401 cites W2148313399 @default.
• W2002452401 cites W2149207625 @default.
• W2002452401 cites W2150734413 @default.
• W2002452401 cites W2152641681 @default.
• W2002452401 cites W2160704477 @default.
• W2002452401 cites W2163665839 @default.
• W2002452401 cites W2168447040 @default.
• W2002452401 cites W2169491483 @default.
• W2002452401 cites W2171400796 @default.
• W2002452401 cites W2249109254 @default.
• W2002452401 cites W2414176255 @default.
• W2002452401 cites W2477567742 @default.
• W2002452401 cites W2484483641 @default.
• W2002452401 cites W3031109839 @default.
• W2002452401 cites W3034187217 @default.
• W2002452401 doi "https://doi.org/10.2147/ibpc.s33958" @default.
• W2002452401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3791632" @default.
• W2002452401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24101882" @default.
• W2002452401 hasPublicationYear "2013" @default.
• W2002452401 type Work @default.
• W2002452401 sameAs 2002452401 @default.
• W2002452401 citedByCount "8" @default.
• W2002452401 countsByYear W20024524012014 @default.
• W2002452401 countsByYear W20024524012015 @default.
• W2002452401 countsByYear W20024524012016 @default.
• W2002452401 countsByYear W20024524012018 @default.
• W2002452401 countsByYear W20024524012020 @default.
• W2002452401 countsByYear W20024524012022 @default.
• W2002452401 crossrefType "journal-article" @default.
• W2002452401 hasAuthorship W2002452401A5028556274 @default.
• W2002452401 hasAuthorship W2002452401A5029674394 @default.
• W2002452401 hasAuthorship W2002452401A5050373267 @default.
• W2002452401 hasAuthorship W2002452401A5070009979 @default.
• W2002452401 hasAuthorship W2002452401A5073388924 @default.
• W2002452401 hasAuthorship W2002452401A5075102218 @default.
• W2002452401 hasBestOaLocation W20024524011 @default.
• W2002452401 hasConcept C126322002 @default.
• W2002452401 hasConcept C127413603 @default.
• W2002452401 hasConcept C134018914 @default.
• W2002452401 hasConcept C164705383 @default.
• W2002452401 hasConcept C2776805190 @default.

• next