FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002456170> ?p ?o ?g. }

• W2002456170 endingPage "188" @default.
• W2002456170 startingPage "180" @default.
• W2002456170 abstract "Although pre-clinical evidence has suggested that partial inhibition of myocardial fatty acid oxidation (FAO) and subsequent switch to greater glucose oxidation for ATP production can prevent ischemia/reperfusion injury, controversy about this approach persists. For example, mice with germline deletion of the FA transporter CD36, exhibited either impaired or unchanged post-ischemic functional recovery despite a 40–60% reduction in FAO rates. Because there are limitations to cardiac studies utilizing whole body CD36 knockout (totalCD36KO) mice, we have now generated an inducible and cardiomyocyte-specific CD36 KO (icCD36KO) mouse to better address the role of cardiomyocyte CD36 and its regulation of FAO and post-ischemic functional recovery. Four to six weeks following CD36 ablation, hearts from icCD36KO mice had significantly decreased FA uptake compared to controls, which was paralleled by significant reductions in intramyocardial triacylglycerol content. Analysis of cardiac energy metabolism using ex vivo working heart perfusions showed that reduced FAO rates were compensated by enhanced glucose oxidation in the hearts from icCD36KO mice. In contrast to the totalCD36KO mice, hearts from icCD36KO mice exhibited significantly improved functional recovery following ischemia/reperfusion (18 min of global no-flow ischemia followed by 40 min of aerobic reperfusion). This improved recovery was associated with lower calculated proton production prior to and following ischemia compared to controls. Moreover, the amount of ATP generated relative to cardiac work was significantly lower in the hearts from icCD36KO mice compared to controls, indicating significantly increased cardiac efficiency in the hearts from icCD36KO mice. These data provide genetic evidence that reduced FAO as a result of diminished CD36-mediated FA uptake improves post-ischemic cardiac efficiency and functional recovery. As such, targeting cardiomyocyte FA uptake and FAO via inhibition of CD36 in the adult myocardium may provide therapeutic benefit during ischemia–reperfusion." @default.
• W2002456170 created "2016-06-24" @default.
• W2002456170 creator A5011691421 @default.
• W2002456170 creator A5022107200 @default.
• W2002456170 creator A5045559776 @default.
• W2002456170 creator A5056419602 @default.
• W2002456170 creator A5065729262 @default.
• W2002456170 creator A5079435038 @default.
• W2002456170 creator A5086076629 @default.
• W2002456170 date "2013-10-01" @default.
• W2002456170 modified "2023-10-18" @default.
• W2002456170 title "Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery" @default.
• W2002456170 cites W1869153889 @default.
• W2002456170 cites W1963627099 @default.
• W2002456170 cites W1979721410 @default.
• W2002456170 cites W1988218038 @default.
• W2002456170 cites W1992956691 @default.
• W2002456170 cites W1999736924 @default.
• W2002456170 cites W2012898950 @default.
• W2002456170 cites W2015781819 @default.
• W2002456170 cites W2017627482 @default.
• W2002456170 cites W2040197119 @default.
• W2002456170 cites W2040722761 @default.
• W2002456170 cites W2053751697 @default.
• W2002456170 cites W2058194924 @default.
• W2002456170 cites W2063954755 @default.
• W2002456170 cites W2073668622 @default.
• W2002456170 cites W2079796426 @default.
• W2002456170 cites W2094165702 @default.
• W2002456170 cites W2098089737 @default.
• W2002456170 cites W2099635702 @default.
• W2002456170 cites W2101475697 @default.
• W2002456170 cites W2105985611 @default.
• W2002456170 cites W2106136075 @default.
• W2002456170 cites W2108789389 @default.
• W2002456170 cites W2109896339 @default.
• W2002456170 cites W2114014847 @default.
• W2002456170 cites W2116039382 @default.
• W2002456170 cites W2118539741 @default.
• W2002456170 cites W2121659762 @default.
• W2002456170 cites W2123519842 @default.
• W2002456170 cites W2124941371 @default.
• W2002456170 cites W2125005881 @default.
• W2002456170 cites W2125404675 @default.
• W2002456170 cites W2128606426 @default.
• W2002456170 cites W2133094378 @default.
• W2002456170 cites W2134699792 @default.
• W2002456170 cites W2136943950 @default.
• W2002456170 cites W2148177741 @default.
• W2002456170 cites W2149074941 @default.
• W2002456170 cites W2153760325 @default.
• W2002456170 cites W2155018420 @default.
• W2002456170 cites W2157785265 @default.
• W2002456170 cites W2160476964 @default.
• W2002456170 cites W2167534313 @default.
• W2002456170 cites W2168709801 @default.
• W2002456170 cites W2169045887 @default.
• W2002456170 doi "https://doi.org/10.1016/j.yjmcc.2013.07.020" @default.
• W2002456170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23948483" @default.
• W2002456170 hasPublicationYear "2013" @default.
• W2002456170 type Work @default.
• W2002456170 sameAs 2002456170 @default.
• W2002456170 citedByCount "57" @default.
• W2002456170 countsByYear W20024561702014 @default.
• W2002456170 countsByYear W20024561702015 @default.
• W2002456170 countsByYear W20024561702016 @default.
• W2002456170 countsByYear W20024561702017 @default.
• W2002456170 countsByYear W20024561702018 @default.
• W2002456170 countsByYear W20024561702019 @default.
• W2002456170 countsByYear W20024561702020 @default.
• W2002456170 countsByYear W20024561702021 @default.
• W2002456170 countsByYear W20024561702022 @default.
• W2002456170 countsByYear W20024561702023 @default.
• W2002456170 crossrefType "journal-article" @default.
• W2002456170 hasAuthorship W2002456170A5011691421 @default.
• W2002456170 hasAuthorship W2002456170A5022107200 @default.
• W2002456170 hasAuthorship W2002456170A5045559776 @default.
• W2002456170 hasAuthorship W2002456170A5056419602 @default.
• W2002456170 hasAuthorship W2002456170A5065729262 @default.
• W2002456170 hasAuthorship W2002456170A5079435038 @default.
• W2002456170 hasAuthorship W2002456170A5086076629 @default.
• W2002456170 hasConcept C126322002 @default.
• W2002456170 hasConcept C134018914 @default.
• W2002456170 hasConcept C164705383 @default.
• W2002456170 hasConcept C170493617 @default.
• W2002456170 hasConcept C185592680 @default.
• W2002456170 hasConcept C2779828298 @default.
• W2002456170 hasConcept C541997718 @default.
• W2002456170 hasConcept C62231903 @default.
• W2002456170 hasConcept C71924100 @default.
• W2002456170 hasConcept C82714985 @default.
• W2002456170 hasConceptScore W2002456170C126322002 @default.
• W2002456170 hasConceptScore W2002456170C134018914 @default.
• W2002456170 hasConceptScore W2002456170C164705383 @default.
• W2002456170 hasConceptScore W2002456170C170493617 @default.
• W2002456170 hasConceptScore W2002456170C185592680 @default.
• W2002456170 hasConceptScore W2002456170C2779828298 @default.
• W2002456170 hasConceptScore W2002456170C541997718 @default.

• next