FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002466754> ?p ?o ?g. }

• W2002466754 endingPage "522" @default.
• W2002466754 startingPage "516" @default.
• W2002466754 abstract "We examined the potential for some of the abnormalities of vascular endothelium found in diabetes mellitus to cause neuropathic changes. Non-diabetic rats were treated for 2 months with the cyclo-oxygenase inhibitor flurbiprofen (5 mg·kg−1·day−1) to reduce prostacyclin production, the nitric oxide synthase inhibitor NG-nitro-L-arginine (5 or 25 mg·kg−1·day−1), or combined treatment. There were dose-dependent reductions in sciatic motor and saphenous sensory conduction velocity. The two inhibitors acted synergistically, thus, the 5–6% motor conduction deficits (p<0.01) produced by either flurbiprofen or NG-nitro-l-arginine (5 mg·kg−1·day−1) increased to 17% (p<0.001) for combined treatment. With NG-nitro-l-arginine (25 mg·kg−1·day−1) and flurbiprofen, motor and sensory conduction velocity were reduced by 23% (p<0.001) and 12% (p<0.001), respectively, matching the deficits following 2-month streptozotocin diabetes. NG-nitro-l-arginine (25 mg·kg−1·day−1) and flurbiprofen together produced a 13% prolongation of the time taken for 80% hypoxic conduction failure in vitro (p<0.05) and a 10% reduction in sciatic capillary density. A second investigation tested an alternative hypothesis that overproduction of nitric oxide was responsible for vascular-related complications in diabetes, the prediction being that NG-nitro-L-arginine (5 mg·kg−1·day−1) would prevent nerve dysfunction. However, rather than prophylaxis during 2-month streptozotocin diabetes, treatment exacerbated nerve abnormalities. Thus, NG-nitro-L-arginine worsened (8%,p<0.001) the motor conduction deficit, there was an 11% increase in hypoxic conduction failure time (p<0.01) and an 11% reduction in endoneurial capillary density (p<0.01). We conclude that overproduction of nitric oxide is unlikely to be involved in the aetiology of experimental diabetic neuropathy. However, endothelial dysfunction resulting in impaired nitric oxide and prostacyclin synthesis could make a substantial contribution." @default.
• W2002466754 created "2016-06-24" @default.
• W2002466754 creator A5009313496 @default.
• W2002466754 creator A5014453522 @default.
• W2002466754 creator A5064776633 @default.
• W2002466754 creator A5082389795 @default.
• W2002466754 date "1993-06-01" @default.
• W2002466754 modified "2023-10-06" @default.
• W2002466754 title "Pharmacological manipulation of vascular endothelium function in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization" @default.
• W2002466754 cites W1484535674 @default.
• W2002466754 cites W1964722373 @default.
• W2002466754 cites W1972009778 @default.
• W2002466754 cites W1972038430 @default.
• W2002466754 cites W1975378457 @default.
• W2002466754 cites W1976192772 @default.
• W2002466754 cites W1980520425 @default.
• W2002466754 cites W1982923029 @default.
• W2002466754 cites W1983286905 @default.
• W2002466754 cites W2001414990 @default.
• W2002466754 cites W2002019101 @default.
• W2002466754 cites W2002312214 @default.
• W2002466754 cites W2002624460 @default.
• W2002466754 cites W2022268466 @default.
• W2002466754 cites W2026343945 @default.
• W2002466754 cites W2029341193 @default.
• W2002466754 cites W2033525828 @default.
• W2002466754 cites W2034535733 @default.
• W2002466754 cites W2038233386 @default.
• W2002466754 cites W2042271610 @default.
• W2002466754 cites W2043480242 @default.
• W2002466754 cites W2044225968 @default.
• W2002466754 cites W2058513354 @default.
• W2002466754 cites W2060407689 @default.
• W2002466754 cites W2063513351 @default.
• W2002466754 cites W2064464513 @default.
• W2002466754 cites W2073713671 @default.
• W2002466754 cites W2074489529 @default.
• W2002466754 cites W2075272342 @default.
• W2002466754 cites W2077824574 @default.
• W2002466754 cites W2077854064 @default.
• W2002466754 cites W2084265146 @default.
• W2002466754 cites W2085141749 @default.
• W2002466754 cites W2088844252 @default.
• W2002466754 cites W2122357131 @default.
• W2002466754 cites W2123979970 @default.
• W2002466754 cites W2167095983 @default.
• W2002466754 cites W2172077475 @default.
• W2002466754 cites W2235517549 @default.
• W2002466754 cites W2273261668 @default.
• W2002466754 cites W2292512265 @default.
• W2002466754 cites W2327269495 @default.
• W2002466754 cites W2340223668 @default.
• W2002466754 cites W2416220929 @default.
• W2002466754 cites W249608969 @default.
• W2002466754 doi "https://doi.org/10.1007/bf02743267" @default.
• W2002466754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8335173" @default.
• W2002466754 hasPublicationYear "1993" @default.
• W2002466754 type Work @default.
• W2002466754 sameAs 2002466754 @default.
• W2002466754 citedByCount "80" @default.
• W2002466754 countsByYear W20024667542014 @default.
• W2002466754 countsByYear W20024667542016 @default.
• W2002466754 countsByYear W20024667542017 @default.
• W2002466754 crossrefType "journal-article" @default.
• W2002466754 hasAuthorship W2002466754A5009313496 @default.
• W2002466754 hasAuthorship W2002466754A5014453522 @default.
• W2002466754 hasAuthorship W2002466754A5064776633 @default.
• W2002466754 hasAuthorship W2002466754A5082389795 @default.
• W2002466754 hasBestOaLocation W20024667541 @default.
• W2002466754 hasConcept C126322002 @default.
• W2002466754 hasConcept C134018914 @default.
• W2002466754 hasConcept C179253579 @default.
• W2002466754 hasConcept C2777622882 @default.
• W2002466754 hasConcept C2778010969 @default.
• W2002466754 hasConcept C2779178840 @default.
• W2002466754 hasConcept C2779280383 @default.
• W2002466754 hasConcept C2781000538 @default.
• W2002466754 hasConcept C2781149210 @default.
• W2002466754 hasConcept C42219234 @default.
• W2002466754 hasConcept C519581460 @default.
• W2002466754 hasConcept C555293320 @default.
• W2002466754 hasConcept C71924100 @default.
• W2002466754 hasConceptScore W2002466754C126322002 @default.
• W2002466754 hasConceptScore W2002466754C134018914 @default.
• W2002466754 hasConceptScore W2002466754C179253579 @default.
• W2002466754 hasConceptScore W2002466754C2777622882 @default.
• W2002466754 hasConceptScore W2002466754C2778010969 @default.
• W2002466754 hasConceptScore W2002466754C2779178840 @default.
• W2002466754 hasConceptScore W2002466754C2779280383 @default.
• W2002466754 hasConceptScore W2002466754C2781000538 @default.
• W2002466754 hasConceptScore W2002466754C2781149210 @default.
• W2002466754 hasConceptScore W2002466754C42219234 @default.
• W2002466754 hasConceptScore W2002466754C519581460 @default.
• W2002466754 hasConceptScore W2002466754C555293320 @default.
• W2002466754 hasConceptScore W2002466754C71924100 @default.
• W2002466754 hasIssue "6" @default.
• W2002466754 hasLocation W20024667541 @default.
• W2002466754 hasLocation W20024667542 @default.

• next