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- W2002482493 abstract "The tetrodotoxin-resistant relaxation to TRH or [met]-enkephalin (ENK) of the isolated segment of rat duodenum was used for studying the modes of action of these neuropeptides. ENK did not inhibit, while TRH inhibited, the spike potentials during the relaxation. The response to ENK was abolished by tetraethylammonium, whereas the response to TRH persisted. The response to TRH was abolished in a Ca-free medium, in which the response to ENK was observable. In K-free medium the effect of ENK was much diminished while TRH was still effective. In Na- or Cl-free medium the response to either TRH or ENK was not abolished. In the smooth muscle of the rat duodenum. TRH is likely to inhibit Ca ion influx, while ENK seems to exert its effect through increasing K ions permeability resulting in hyperpolarization." @default.
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- W2002482493 date "1980-12-01" @default.
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- W2002482493 title "Differential mode of action of thyrotropin-releasing hormone and enkephalin on the smooth muscle of rat duodenum" @default.
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- W2002482493 doi "https://doi.org/10.1016/0024-3205(80)90488-9" @default.
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