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- W2002487398 abstract "Background: The factor V Leiden mutation affects 6% of the United States population and is known to be associated with venous thrombosis. We identify, herein, 30 individuals with the Leiden mutation and known arterial thromboembolic events. Methods: The factor V mutation was assessed using polymerase chain reaction. Results: In the 16 patients sustaining a cerebrovascular accident, the mean age was 44.1 and 11 (69%) were younger than 50. Similarly, the 13 patients presenting with an acute myocardial infarction were relatively young with a mean age of 45.5, and 9 (65%) patients presented at less than 50 years of age. Radiographic information was available for 19 patients in this study. No significant arterial atherosclerotic disease was demonstrated in 18 (95%) of these patients. Conclusions: This study demonstrates an association between the factor V Leiden mutation and the development of unexplained arterial thromboembolic events, especially in younger patients without existing atherosclerotic disease." @default.
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- W2002487398 date "1998-08-01" @default.
- W2002487398 modified "2023-10-18" @default.
- W2002487398 title "Arterial thromboembolic events in patients with the factor V Leiden mutation" @default.
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- W2002487398 doi "https://doi.org/10.1016/s0002-9610(98)00161-5" @default.
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