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- W2002489327 abstract "Abstract Background Recognition of microbial products through Toll-like receptors (TLRs) initiates inflammatory responses orchestrated by innate immune cells such as dendritic cells (DCs). As these cells are patrolling mucosal surfaces, a portal of entry for various pathogens including human immunodeficiency virus type-1 (HIV-1), we investigated the impact of TLR stimulation on productive HIV-1 infection of DCs and viral spreading to CD4 + T cells. Results We report here that engagement of TLR2 on DCs increases HIV-1 transmission toward CD4 + T cells by primarily affecting de novo virus production by DCs. No noticeable and consistent effect was observed following engagement of TLR5, 7 and 9. Additional studies indicated that both HIV-1 infection of DCs and DC-mediated virus transmission to CD4 + T cells were reduced upon TLR4 triggering due to secretion of type-I interferons. Conclusion It can thus be proposed that exposure of DCs to TLR2-binding bacterial constituents derived, for example, from pathogens causing sexually transmissible infections, might influence the process of DC-mediated viral dissemination, a phenomenon that might contribute to a more rapid disease progression." @default.
- W2002489327 created "2016-06-24" @default.
- W2002489327 creator A5012027177 @default.
- W2002489327 creator A5018885131 @default.
- W2002489327 creator A5039852039 @default.
- W2002489327 creator A5044038474 @default.
- W2002489327 date "2009-05-06" @default.
- W2002489327 modified "2023-09-26" @default.
- W2002489327 title "TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+T cells" @default.
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