FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002494798> ?p ?o ?g. }

• W2002494798 endingPage "175" @default.
• W2002494798 startingPage "167" @default.
• W2002494798 abstract "The cytotoxic and genotoxic effects of phenacetin and paracetamol were examined in monolayer cultures of hepatocytes isolated from the mouse, hamster, rat and guinea pig. No marked increase in unscheduled DNA synthesis (UDS) after exposing hepatocytes from any of the species to phenacetin was observed. At cytotoxic concentrations of paracetamol, an increased UDS in mouse hepatocytes in vitro was observed. Pretreatment of the mice by inducers of drug-metabolizing enzymes, such as 3-methylcholanthrene and Aroclor 1254, lowered the concentration threshold for the toxic responses. With rat hepatocytes only a minor increase in UDS was noted, while with hepatocytes from hamsters and guinea pigs in fact a decrease was seen. The narrow range observed between the cytotoxic and genotoxic effects of paracetamol makes it difficult to predict whether the initial DNA damage could lead to a mutation or whether the cells will die before the mutation is expressed. With respect to the cytotoxic effects, hamster hepatocytes were found to be most susceptible to paracetamol, followed by mouse, while rat and guinea pig were less affected. These data were in accordance with in vivo findings (Davis et al., 1974), indicating the potential value of hepatocyte culture when screening for possible liver toxic substances." @default.
• W2002494798 created "2016-06-24" @default.
• W2002494798 creator A5011676965 @default.
• W2002494798 creator A5014466291 @default.
• W2002494798 date "1986-06-01" @default.
• W2002494798 modified "2023-10-16" @default.
• W2002494798 title "Species differences in cytotoxic and genotoxic effects of phenacetin and paracetamol in primary monolayer cultures of hepatocytes" @default.
• W2002494798 cites W1490154674 @default.
• W2002494798 cites W1906197854 @default.
• W2002494798 cites W1932583042 @default.
• W2002494798 cites W1968541657 @default.
• W2002494798 cites W1971296064 @default.
• W2002494798 cites W1973064256 @default.
• W2002494798 cites W1977327746 @default.
• W2002494798 cites W1986255994 @default.
• W2002494798 cites W1993549053 @default.
• W2002494798 cites W1994620628 @default.
• W2002494798 cites W2006039006 @default.
• W2002494798 cites W2006499219 @default.
• W2002494798 cites W2009635828 @default.
• W2002494798 cites W2016390817 @default.
• W2002494798 cites W2016885914 @default.
• W2002494798 cites W2018683888 @default.
• W2002494798 cites W2024153462 @default.
• W2002494798 cites W2030176054 @default.
• W2002494798 cites W2031286860 @default.
• W2002494798 cites W2035747342 @default.
• W2002494798 cites W2048609893 @default.
• W2002494798 cites W2061255334 @default.
• W2002494798 cites W2075940275 @default.
• W2002494798 cites W2078330627 @default.
• W2002494798 cites W2083141208 @default.
• W2002494798 cites W2084992276 @default.
• W2002494798 cites W2133260297 @default.
• W2002494798 cites W2143542298 @default.
• W2002494798 cites W2165217388 @default.
• W2002494798 doi "https://doi.org/10.1016/0165-1161(86)90007-5" @default.
• W2002494798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3713718" @default.
• W2002494798 hasPublicationYear "1986" @default.
• W2002494798 type Work @default.
• W2002494798 sameAs 2002494798 @default.
• W2002494798 citedByCount "20" @default.
• W2002494798 countsByYear W20024947982021 @default.
• W2002494798 crossrefType "journal-article" @default.
• W2002494798 hasAuthorship W2002494798A5011676965 @default.
• W2002494798 hasAuthorship W2002494798A5014466291 @default.
• W2002494798 hasConcept C109316439 @default.
• W2002494798 hasConcept C134018914 @default.
• W2002494798 hasConcept C153911025 @default.
• W2002494798 hasConcept C154317977 @default.
• W2002494798 hasConcept C185592680 @default.
• W2002494798 hasConcept C202751555 @default.
• W2002494798 hasConcept C207001950 @default.
• W2002494798 hasConcept C2775922563 @default.
• W2002494798 hasConcept C2776200302 @default.
• W2002494798 hasConcept C2776639595 @default.
• W2002494798 hasConcept C2777755551 @default.
• W2002494798 hasConcept C2778575167 @default.
• W2002494798 hasConcept C2778722691 @default.
• W2002494798 hasConcept C2778815084 @default.
• W2002494798 hasConcept C54355233 @default.
• W2002494798 hasConcept C552990157 @default.
• W2002494798 hasConcept C55493867 @default.
• W2002494798 hasConcept C86803240 @default.
• W2002494798 hasConcept C98274493 @default.
• W2002494798 hasConceptScore W2002494798C109316439 @default.
• W2002494798 hasConceptScore W2002494798C134018914 @default.
• W2002494798 hasConceptScore W2002494798C153911025 @default.
• W2002494798 hasConceptScore W2002494798C154317977 @default.
• W2002494798 hasConceptScore W2002494798C185592680 @default.
• W2002494798 hasConceptScore W2002494798C202751555 @default.
• W2002494798 hasConceptScore W2002494798C207001950 @default.
• W2002494798 hasConceptScore W2002494798C2775922563 @default.
• W2002494798 hasConceptScore W2002494798C2776200302 @default.
• W2002494798 hasConceptScore W2002494798C2776639595 @default.
• W2002494798 hasConceptScore W2002494798C2777755551 @default.
• W2002494798 hasConceptScore W2002494798C2778575167 @default.
• W2002494798 hasConceptScore W2002494798C2778722691 @default.
• W2002494798 hasConceptScore W2002494798C2778815084 @default.
• W2002494798 hasConceptScore W2002494798C54355233 @default.
• W2002494798 hasConceptScore W2002494798C552990157 @default.
• W2002494798 hasConceptScore W2002494798C55493867 @default.
• W2002494798 hasConceptScore W2002494798C86803240 @default.
• W2002494798 hasConceptScore W2002494798C98274493 @default.
• W2002494798 hasIssue "3" @default.
• W2002494798 hasLocation W20024947981 @default.
• W2002494798 hasLocation W20024947982 @default.
• W2002494798 hasOpenAccess W2002494798 @default.
• W2002494798 hasPrimaryLocation W20024947981 @default.
• W2002494798 hasRelatedWork W1978870712 @default.
• W2002494798 hasRelatedWork W1992624650 @default.
• W2002494798 hasRelatedWork W1993549053 @default.
• W2002494798 hasRelatedWork W2002494798 @default.
• W2002494798 hasRelatedWork W2045135664 @default.
• W2002494798 hasRelatedWork W2375697750 @default.
• W2002494798 hasRelatedWork W2412357694 @default.
• W2002494798 hasRelatedWork W2416964709 @default.
• W2002494798 hasRelatedWork W2751113012 @default.

• next