FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002494961> ?p ?o ?g. }

• W2002494961 endingPage "1005" @default.
• W2002494961 startingPage "1001" @default.
• W2002494961 abstract "Clinical and pathologic observations have prompted the categorization of malignant melanoma into 4 subtypes. Although some authorities challenge the value of this classification, nevertheless it is generally accepted that lentigo maligna (LM), or melanoma on sun-damaged skin, has a different biological behavior than so-called superficial spreading melanoma (SSM), at least in the early stage of its evolution. To characterize some aspects of this different behavior, the in situ phase of SSM and LM was studied using immunohistochemical methods. Seventeen cases of SSM in situ and 13 cases of LM were chosen for the study. All cases qualified with strict histologic criteria. Sections from these lesions were stained with antibodies against HMB-45 antigen, basic fibroblast growth factor (bFGF), proliferating cell nuclear antigen (PCNA), and factor VIII. Semiquantitative analysis was performed. Cases classified as either LM or SSM corresponded well to the epidemiologic and clinical characteristics as described in the literature; that is, LM appeared in older patients and occurred mostly on the face, whereas SSM occurred mostly on the trunk and lower limbs. Although no difference in HMB-45 stain was observed, melanoctyes of SSM showed greater proliferative activity, as reflected by PCNA stain (P < 0.02) and higher levels of bFGF (P < 0.001), than melanocytes of LM. More blood vessels were counted under SSM than under LM (P < 0.05). These results are in accordance with the biological behavior of SSM and LM, that is, the longer in situ phase of the latter. bFGF is both a growth factor for melanocytes and an angiogentic factor. The differences in PCNA, a proliferation marker, and blood vessel count may be related to the bFGF effect. Thus this study reveals some of the biological differences between LM and SSM. Location and sun exposure habits may contribute to these differences, which already exist in the in situ phase." @default.
• W2002494961 created "2016-06-24" @default.
• W2002494961 creator A5005258341 @default.
• W2002494961 creator A5030193985 @default.
• W2002494961 creator A5041559073 @default.
• W2002494961 creator A5058390477 @default.
• W2002494961 creator A5079790031 @default.
• W2002494961 date "2002-10-01" @default.
• W2002494961 modified "2023-10-16" @default.
• W2002494961 title "Lentigo maligna and superficial spreading melanoma are different in their in situ phase: An immunohistochemical study" @default.
• W2002494961 cites W1965432062 @default.
• W2002494961 cites W1966166325 @default.
• W2002494961 cites W1972206478 @default.
• W2002494961 cites W1976650472 @default.
• W2002494961 cites W1979403186 @default.
• W2002494961 cites W1981145995 @default.
• W2002494961 cites W1982150427 @default.
• W2002494961 cites W2000000541 @default.
• W2002494961 cites W2003831501 @default.
• W2002494961 cites W2026251634 @default.
• W2002494961 cites W2033208185 @default.
• W2002494961 cites W2042469742 @default.
• W2002494961 cites W2042820983 @default.
• W2002494961 cites W2046756819 @default.
• W2002494961 cites W2070833310 @default.
• W2002494961 cites W2085447097 @default.
• W2002494961 cites W2086903333 @default.
• W2002494961 cites W2090557075 @default.
• W2002494961 cites W2107667201 @default.
• W2002494961 cites W2121737245 @default.
• W2002494961 cites W2136120524 @default.
• W2002494961 cites W2158743409 @default.
• W2002494961 cites W63240848 @default.
• W2002494961 doi "https://doi.org/10.1053/hupa.2002.124014" @default.
• W2002494961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12395373" @default.
• W2002494961 hasPublicationYear "2002" @default.
• W2002494961 type Work @default.
• W2002494961 sameAs 2002494961 @default.
• W2002494961 citedByCount "19" @default.
• W2002494961 countsByYear W20024949612012 @default.
• W2002494961 countsByYear W20024949612013 @default.
• W2002494961 countsByYear W20024949612015 @default.
• W2002494961 countsByYear W20024949612016 @default.
• W2002494961 countsByYear W20024949612018 @default.
• W2002494961 crossrefType "journal-article" @default.
• W2002494961 hasAuthorship W2002494961A5005258341 @default.
• W2002494961 hasAuthorship W2002494961A5030193985 @default.
• W2002494961 hasAuthorship W2002494961A5041559073 @default.
• W2002494961 hasAuthorship W2002494961A5058390477 @default.
• W2002494961 hasAuthorship W2002494961A5079790031 @default.
• W2002494961 hasConcept C126322002 @default.
• W2002494961 hasConcept C142724271 @default.
• W2002494961 hasConcept C170493617 @default.
• W2002494961 hasConcept C200583388 @default.
• W2002494961 hasConcept C204232928 @default.
• W2002494961 hasConcept C2775960820 @default.
• W2002494961 hasConcept C2777264407 @default.
• W2002494961 hasConcept C2777393561 @default.
• W2002494961 hasConcept C2777587049 @default.
• W2002494961 hasConcept C2777658100 @default.
• W2002494961 hasConcept C2780667408 @default.
• W2002494961 hasConcept C2781294515 @default.
• W2002494961 hasConcept C34688535 @default.
• W2002494961 hasConcept C502942594 @default.
• W2002494961 hasConcept C71924100 @default.
• W2002494961 hasConcept C74864618 @default.
• W2002494961 hasConceptScore W2002494961C126322002 @default.
• W2002494961 hasConceptScore W2002494961C142724271 @default.
• W2002494961 hasConceptScore W2002494961C170493617 @default.
• W2002494961 hasConceptScore W2002494961C200583388 @default.
• W2002494961 hasConceptScore W2002494961C204232928 @default.
• W2002494961 hasConceptScore W2002494961C2775960820 @default.
• W2002494961 hasConceptScore W2002494961C2777264407 @default.
• W2002494961 hasConceptScore W2002494961C2777393561 @default.
• W2002494961 hasConceptScore W2002494961C2777587049 @default.
• W2002494961 hasConceptScore W2002494961C2777658100 @default.
• W2002494961 hasConceptScore W2002494961C2780667408 @default.
• W2002494961 hasConceptScore W2002494961C2781294515 @default.
• W2002494961 hasConceptScore W2002494961C34688535 @default.
• W2002494961 hasConceptScore W2002494961C502942594 @default.
• W2002494961 hasConceptScore W2002494961C71924100 @default.
• W2002494961 hasConceptScore W2002494961C74864618 @default.
• W2002494961 hasIssue "10" @default.
• W2002494961 hasLocation W20024949611 @default.
• W2002494961 hasLocation W20024949612 @default.
• W2002494961 hasOpenAccess W2002494961 @default.
• W2002494961 hasPrimaryLocation W20024949611 @default.
• W2002494961 hasRelatedWork W1983427607 @default.
• W2002494961 hasRelatedWork W1990163509 @default.
• W2002494961 hasRelatedWork W2002494961 @default.
• W2002494961 hasRelatedWork W2035464821 @default.
• W2002494961 hasRelatedWork W2078185735 @default.
• W2002494961 hasRelatedWork W2129234309 @default.
• W2002494961 hasRelatedWork W2140631454 @default.
• W2002494961 hasRelatedWork W2884769110 @default.
• W2002494961 hasRelatedWork W3025253837 @default.
• W2002494961 hasRelatedWork W4298228075 @default.
• W2002494961 hasVolume "33" @default.

• next