FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002505229> ?p ?o ?g. }

• W2002505229 endingPage "562" @default.
• W2002505229 startingPage "562" @default.
• W2002505229 abstract "Kasabach-Merritt Syndrome (KMS) is seen in children with large vascular tumors. KMS is characterized by very low platelet counts and a consumption of coagulation factors causing life-threatening complications. It has been proposed that thrombopenia in these patients is caused by intratumoral trapping of platelets. The truncated form of the cMpl-receptor ligand thrombopoietin, pegylated human megakaryocyte growth and development factor (Peg-rHuMGDF), is an agent that stimulates platelet production. We hypothesized that stimulation of the platelet production would prevent the life-threatening complications of patients with KMS owing to low platelet counts. In a mouse model of KMS, with tumors derived from a hemangioendothelioma cell line, we studied the effect of Peg-rHuMGDF. Treatment with Peg-rHuMGDF (10 μg/kg/day intraperitoneally) increased platelet counts by 7–8-fold compared with control tumor-bearing mice after 11 d of treatment (p< 0.001, n= 8). Survival was significantly increased, with 50% of treated animals alive at 1 mo versus 0% in untreated controls. Interestingly, we also observed an inhibition of tumor growth by 75% (p< 0.001, n= 8). Hematoxylin and eosin staining showed fresh fibrin clots in the treated tumors, suggesting that higher platelet counts caused intravascular thrombosis of tumor vessels. We conclude that increased platelet production in this model of KMS resulted in an antivascular tumor effect via platelet trapping. Further, we propose that thrombopoietin may be of critical value in preventing life-threatening complications from KMS." @default.
• W2002505229 created "2016-06-24" @default.
• W2002505229 creator A5019188939 @default.
• W2002505229 creator A5022897881 @default.
• W2002505229 creator A5062035206 @default.
• W2002505229 creator A5072526377 @default.
• W2002505229 creator A5075631226 @default.
• W2002505229 date "1999-11-01" @default.
• W2002505229 modified "2023-09-27" @default.
• W2002505229 title "Treatment of the Kasabach-Merritt Syndrome with Pegylated Recombinant Human Megakaryocyte Growth and Development Factor in Mice: Elevated Platelet Counts, Prolonged Survival, and Tumor Growth Inhibition" @default.
• W2002505229 cites W1949405420 @default.
• W2002505229 cites W1982802846 @default.
• W2002505229 cites W1983612778 @default.
• W2002505229 cites W1987609377 @default.
• W2002505229 cites W1990943205 @default.
• W2002505229 cites W1992962257 @default.
• W2002505229 cites W2000558617 @default.
• W2002505229 cites W2019850232 @default.
• W2002505229 cites W2021382762 @default.
• W2002505229 cites W2033128975 @default.
• W2002505229 cites W2035384358 @default.
• W2002505229 cites W2038818733 @default.
• W2002505229 cites W2039973874 @default.
• W2002505229 cites W2049705652 @default.
• W2002505229 cites W2061382718 @default.
• W2002505229 cites W2067593747 @default.
• W2002505229 cites W2143531841 @default.
• W2002505229 cites W2158134782 @default.
• W2002505229 cites W2321503226 @default.
• W2002505229 doi "https://doi.org/10.1203/00006450-199911000-00012" @default.
• W2002505229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10541319" @default.
• W2002505229 hasPublicationYear "1999" @default.
• W2002505229 type Work @default.
• W2002505229 sameAs 2002505229 @default.
• W2002505229 citedByCount "20" @default.
• W2002505229 countsByYear W20025052292012 @default.
• W2002505229 countsByYear W20025052292013 @default.
• W2002505229 countsByYear W20025052292016 @default.
• W2002505229 countsByYear W20025052292017 @default.
• W2002505229 countsByYear W20025052292018 @default.
• W2002505229 countsByYear W20025052292022 @default.
• W2002505229 crossrefType "journal-article" @default.
• W2002505229 hasAuthorship W2002505229A5019188939 @default.
• W2002505229 hasAuthorship W2002505229A5022897881 @default.
• W2002505229 hasAuthorship W2002505229A5062035206 @default.
• W2002505229 hasAuthorship W2002505229A5072526377 @default.
• W2002505229 hasAuthorship W2002505229A5075631226 @default.
• W2002505229 hasBestOaLocation W20025052291 @default.
• W2002505229 hasConcept C109159458 @default.
• W2002505229 hasConcept C125473707 @default.
• W2002505229 hasConcept C126322002 @default.
• W2002505229 hasConcept C134018914 @default.
• W2002505229 hasConcept C170493617 @default.
• W2002505229 hasConcept C203014093 @default.
• W2002505229 hasConcept C204232928 @default.
• W2002505229 hasConcept C2775960820 @default.
• W2002505229 hasConcept C2776958478 @default.
• W2002505229 hasConcept C2777863708 @default.
• W2002505229 hasConcept C2778734968 @default.
• W2002505229 hasConcept C2779705218 @default.
• W2002505229 hasConcept C28328180 @default.
• W2002505229 hasConcept C54355233 @default.
• W2002505229 hasConcept C71924100 @default.
• W2002505229 hasConcept C86803240 @default.
• W2002505229 hasConcept C89560881 @default.
• W2002505229 hasConceptScore W2002505229C109159458 @default.
• W2002505229 hasConceptScore W2002505229C125473707 @default.
• W2002505229 hasConceptScore W2002505229C126322002 @default.
• W2002505229 hasConceptScore W2002505229C134018914 @default.
• W2002505229 hasConceptScore W2002505229C170493617 @default.
• W2002505229 hasConceptScore W2002505229C203014093 @default.
• W2002505229 hasConceptScore W2002505229C204232928 @default.
• W2002505229 hasConceptScore W2002505229C2775960820 @default.
• W2002505229 hasConceptScore W2002505229C2776958478 @default.
• W2002505229 hasConceptScore W2002505229C2777863708 @default.
• W2002505229 hasConceptScore W2002505229C2778734968 @default.
• W2002505229 hasConceptScore W2002505229C2779705218 @default.
• W2002505229 hasConceptScore W2002505229C28328180 @default.
• W2002505229 hasConceptScore W2002505229C54355233 @default.
• W2002505229 hasConceptScore W2002505229C71924100 @default.
• W2002505229 hasConceptScore W2002505229C86803240 @default.
• W2002505229 hasConceptScore W2002505229C89560881 @default.
• W2002505229 hasIssue "5" @default.
• W2002505229 hasLocation W20025052291 @default.
• W2002505229 hasLocation W20025052292 @default.
• W2002505229 hasOpenAccess W2002505229 @default.
• W2002505229 hasPrimaryLocation W20025052291 @default.
• W2002505229 hasRelatedWork W1982913438 @default.
• W2002505229 hasRelatedWork W2056918958 @default.
• W2002505229 hasRelatedWork W2243837586 @default.
• W2002505229 hasRelatedWork W2332253499 @default.
• W2002505229 hasRelatedWork W2344941588 @default.
• W2002505229 hasRelatedWork W2400897437 @default.
• W2002505229 hasRelatedWork W2586955483 @default.
• W2002505229 hasRelatedWork W2593811684 @default.
• W2002505229 hasRelatedWork W2851093530 @default.
• W2002505229 hasRelatedWork W4248876388 @default.
• W2002505229 hasVolume "46" @default.

• next