FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002507752> ?p ?o ?g. }

• W2002507752 endingPage "1104" @default.
• W2002507752 startingPage "1100" @default.
• W2002507752 abstract "Abstract Previous results from our laboratory have suggested that opioid receptors are involved in ischemic preconditioning (PC) in rat heart. Furthermore, other investigators have suggested that μ- and δ-opioid receptors mediate analgesia and hypoxic cerebral vasodilatation via opening of ATP-sensitive K + (K ATP ) channels. Thus, the purpose of the present study was to test the hypothesis that activation of opioid receptors mimics the cardioprotective effect of ischemic PC and that this effect is produced by activation of K ATP channels in the rat heart. Anesthetized open-chest Wistar rats were subjected to six different protocols. All groups were subjected to 30 minutes of occlusion and 2 hours of reperfusion. Ischemic PC was elicited by three 5-minute occlusion periods interspersed with 5 minutes of reperfusion. Similarly, morphine-induced PC was elicited by three 5-minute drug infusions (100 μg/kg IV) interspersed with 5-minute drug-free periods before the prolonged 30-minute occlusion. Infarct size (IS) as a percentage of the area at risk (AAR) was determined by triphenyltetrazolium staining. Ischemic PC and morphine infusions resulted in similar reductions in IS/AAR from 56±5% to 11±3% and 12±5%, respectively ( P <.05). Administration of glibenclamide (0.3 mg/kg IV), a K ATP channel antagonist, or naloxone (3 mg/kg IV), a nonselective opioid receptor antagonist, both blocked the cardioprotective effects of morphine. These results indicate that opioid receptor stimulation results in a reduction in infarct size similar to that produced by ischemic PC. The effect of morphine is most likely mediated via an opioid receptor-K ATP channel–linked mechanism in the rat heart, since glibenclamide abolished its protection." @default.
• W2002507752 created "2016-06-24" @default.
• W2002507752 creator A5026429897 @default.
• W2002507752 creator A5028528550 @default.
• W2002507752 creator A5030692703 @default.
• W2002507752 date "1996-06-01" @default.
• W2002507752 modified "2023-10-01" @default.
• W2002507752 title "Morphine Mimics the Cardioprotective Effect of Ischemic Preconditioning via a Glibenclamide-Sensitive Mechanism in the Rat Heart" @default.
• W2002507752 cites W1573285735 @default.
• W2002507752 cites W1990739688 @default.
• W2002507752 cites W1991357841 @default.
• W2002507752 cites W1992823328 @default.
• W2002507752 cites W2000857078 @default.
• W2002507752 cites W2030592905 @default.
• W2002507752 cites W2038077272 @default.
• W2002507752 cites W2043460209 @default.
• W2002507752 cites W2059277415 @default.
• W2002507752 cites W2065218555 @default.
• W2002507752 cites W2094149060 @default.
• W2002507752 cites W2097550685 @default.
• W2002507752 cites W2109277649 @default.
• W2002507752 cites W2114382165 @default.
• W2002507752 cites W2118347540 @default.
• W2002507752 cites W2165498557 @default.
• W2002507752 cites W27551127 @default.
• W2002507752 cites W4250184701 @default.
• W2002507752 doi "https://doi.org/10.1161/01.res.78.6.1100" @default.
• W2002507752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8635241" @default.
• W2002507752 hasPublicationYear "1996" @default.
• W2002507752 type Work @default.
• W2002507752 sameAs 2002507752 @default.
• W2002507752 citedByCount "350" @default.
• W2002507752 countsByYear W20025077522012 @default.
• W2002507752 countsByYear W20025077522013 @default.
• W2002507752 countsByYear W20025077522014 @default.
• W2002507752 countsByYear W20025077522015 @default.
• W2002507752 countsByYear W20025077522016 @default.
• W2002507752 countsByYear W20025077522017 @default.
• W2002507752 countsByYear W20025077522018 @default.
• W2002507752 countsByYear W20025077522020 @default.
• W2002507752 countsByYear W20025077522021 @default.
• W2002507752 countsByYear W20025077522022 @default.
• W2002507752 countsByYear W20025077522023 @default.
• W2002507752 crossrefType "journal-article" @default.
• W2002507752 hasAuthorship W2002507752A5026429897 @default.
• W2002507752 hasAuthorship W2002507752A5028528550 @default.
• W2002507752 hasAuthorship W2002507752A5030692703 @default.
• W2002507752 hasConcept C126322002 @default.
• W2002507752 hasConcept C134018914 @default.
• W2002507752 hasConcept C170493617 @default.
• W2002507752 hasConcept C24998067 @default.
• W2002507752 hasConcept C2775962371 @default.
• W2002507752 hasConcept C2776885963 @default.
• W2002507752 hasConcept C2777389121 @default.
• W2002507752 hasConcept C2778750930 @default.
• W2002507752 hasConcept C2779311647 @default.
• W2002507752 hasConcept C2779768347 @default.
• W2002507752 hasConcept C2779886867 @default.
• W2002507752 hasConcept C2781063702 @default.
• W2002507752 hasConcept C42219234 @default.
• W2002507752 hasConcept C541997718 @default.
• W2002507752 hasConcept C555293320 @default.
• W2002507752 hasConcept C71924100 @default.
• W2002507752 hasConcept C98274493 @default.
• W2002507752 hasConceptScore W2002507752C126322002 @default.
• W2002507752 hasConceptScore W2002507752C134018914 @default.
• W2002507752 hasConceptScore W2002507752C170493617 @default.
• W2002507752 hasConceptScore W2002507752C24998067 @default.
• W2002507752 hasConceptScore W2002507752C2775962371 @default.
• W2002507752 hasConceptScore W2002507752C2776885963 @default.
• W2002507752 hasConceptScore W2002507752C2777389121 @default.
• W2002507752 hasConceptScore W2002507752C2778750930 @default.
• W2002507752 hasConceptScore W2002507752C2779311647 @default.
• W2002507752 hasConceptScore W2002507752C2779768347 @default.
• W2002507752 hasConceptScore W2002507752C2779886867 @default.
• W2002507752 hasConceptScore W2002507752C2781063702 @default.
• W2002507752 hasConceptScore W2002507752C42219234 @default.
• W2002507752 hasConceptScore W2002507752C541997718 @default.
• W2002507752 hasConceptScore W2002507752C555293320 @default.
• W2002507752 hasConceptScore W2002507752C71924100 @default.
• W2002507752 hasConceptScore W2002507752C98274493 @default.
• W2002507752 hasIssue "6" @default.
• W2002507752 hasLocation W20025077521 @default.
• W2002507752 hasLocation W20025077522 @default.
• W2002507752 hasOpenAccess W2002507752 @default.
• W2002507752 hasPrimaryLocation W20025077521 @default.
• W2002507752 hasRelatedWork W1898004705 @default.
• W2002507752 hasRelatedWork W2041870569 @default.
• W2002507752 hasRelatedWork W2067032885 @default.
• W2002507752 hasRelatedWork W2073860477 @default.
• W2002507752 hasRelatedWork W2089497531 @default.
• W2002507752 hasRelatedWork W2097635080 @default.
• W2002507752 hasRelatedWork W2114391438 @default.
• W2002507752 hasRelatedWork W2174846875 @default.
• W2002507752 hasRelatedWork W2380912844 @default.
• W2002507752 hasRelatedWork W2898111958 @default.
• W2002507752 hasVolume "78" @default.
• W2002507752 isParatext "false" @default.

• next