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• W2002507951 abstract "<b><i>Background:</i></b> Up to now, the regulation of adrenarche remains a myth although ACTH may possibly play an important role. <b><i>Methods:</i></b> Urinary steroid profiling by gas chromatography-mass spectrometry was used to study non-invasively the adrenarchal steroid metabolome in 13 children aged 6-16 years with partial or complete hypopituitarism (HP) whose ACTH/cortisol axis was affected and compared it with 24 healthy age-matched controls. The sum of DHEA, 16α-hydroxy-DHEA and 3β,16α,17β-androstenetriol served as markers for adrenarche parameters (AP). The excretion rates of major urinary cortisol metabolites were also determined. <b><i>Results:</i></b> The excretion rates for AP were significantly lower for the HP subjects than for the controls (p < 0.001). After dividing the HP group into a subgroup treated with hydrocortisone (HC) and an HC-untreated subgroup, a significant difference for AP remained for each subgroup when compared to the control group (p < 0.001 and p = 0.045, respectively). Treatment with HC had no influence on AP. <b><i>Conclusion:</i></b> The data imply indirectly a significant contribution of ACTH to the regulation of adrenarche. Our results also signify important diagnostic information: absent adrenarche can be indicative of ACTH deficiency." @default.
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• W2002507951 date "2013-01-01" @default.
• W2002507951 modified "2023-10-17" @default.
• W2002507951 title "Absent Adrenarche in Children with Hypopituitarism: A Study Based on Urinary Steroid Metabolomics" @default.
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• W2002507951 doi "https://doi.org/10.1159/000351705" @default.
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