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- W2002510122 abstract "The Central Dogma of molecular biology describes the one-way flow of information from DNA to RNA to protein, but it excludes the possibility of proteinaceous infectious agents (prions) such as those implicated in certain neurological diseases like scrapie and Creutzfeldt-Jakob disease. Rather than carrying genetic information like viruses, prions appear to carry functional information which they use to alter the meaníng of host genes during their cycle of replication. Prions represent an important counter-example to the accepted theories of molecular genetics, in which biological specificity is determined completely by macromolecular sequence information. Criticism of the proposition that organisms can be constructed from their genes leads to the conclusion that the neo-Darwinian interpretation of the theory of evolution is seriously deficient, especially in relation to the prebiotic phase. It is suggested that the evolutionary emergence and development of biological function, or teleopoiesis, is as important a determinant of biological evolution as the mutation and selection of genetic information." @default.
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- W2002510122 date "1989-09-01" @default.
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- W2002510122 title "Genetic information and the determination of functional organization in biological systems" @default.
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- W2002510122 doi "https://doi.org/10.1002/sres.3850060305" @default.
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