Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002518761> ?p ?o ?g. }
- W2002518761 endingPage "87" @default.
- W2002518761 startingPage "78" @default.
- W2002518761 abstract "Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Accordingly, the enhancement of this crosstalk represents a promising approach to achieve successful bioengineering of human hair follicles. The present article summarizes the techniques, both currently available and potentially feasible, to promote epithelial–mesenchymal interactions (EMIs) necessary for human hair follicle regeneration. The strategies include the preparation of epithelial components with high receptivity to trichogenic dermal signals and/or mesenchymal cell populations with potent hair inductive capacity. In this regard, bulge epithelial stem cells, keratinocytes predisposed to hair follicle fate or keratinocyte precursor cells with plasticity may provide favorable epithelial cell populations. Dermal papilla cells sustaining intrinsic hair inductive capacity, putative dermal papilla precursor cells in the dermal sheath/neonatal dermis or trichogenic dermal cells derived from undifferentiated stem/progenitor cells are promising candidates as hair inductive dermal cells. The most established protocol for in vivo hair follicle reconstitution is co-grafting of epithelial and mesenchymal components into immunodeficient mice. In theory, combination of individually optimized cellular components of respective lineages should elicit most intensive EMIs to form hair follicles. Still, EMIs can be further ameliorated by the modulation of non-cell autonomous conditions, including cell compartmentalization to replicate the positional relationship in vivo and humanization of host environment by preparing human stromal bed. These approaches may not always synergistically intensify EMIs, however, step-by-step investigation probing optimal combinations should maximally enhance EMIs to achieve successful human hair follicle bioengineering." @default.
- W2002518761 created "2016-06-24" @default.
- W2002518761 creator A5002193039 @default.
- W2002518761 creator A5006522006 @default.
- W2002518761 date "2013-05-01" @default.
- W2002518761 modified "2023-10-15" @default.
- W2002518761 title "Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering" @default.
- W2002518761 cites W1484268538 @default.
- W2002518761 cites W1501867271 @default.
- W2002518761 cites W1503578591 @default.
- W2002518761 cites W1532399084 @default.
- W2002518761 cites W1566314871 @default.
- W2002518761 cites W1631740935 @default.
- W2002518761 cites W1966857658 @default.
- W2002518761 cites W1967083377 @default.
- W2002518761 cites W1967265497 @default.
- W2002518761 cites W1967273196 @default.
- W2002518761 cites W1969012267 @default.
- W2002518761 cites W1970177659 @default.
- W2002518761 cites W1971143669 @default.
- W2002518761 cites W1973757465 @default.
- W2002518761 cites W1975847309 @default.
- W2002518761 cites W1977258206 @default.
- W2002518761 cites W1980332250 @default.
- W2002518761 cites W1982724912 @default.
- W2002518761 cites W1984451096 @default.
- W2002518761 cites W1985011898 @default.
- W2002518761 cites W1985191536 @default.
- W2002518761 cites W1986285972 @default.
- W2002518761 cites W1987407032 @default.
- W2002518761 cites W1989404379 @default.
- W2002518761 cites W1990768206 @default.
- W2002518761 cites W1998479150 @default.
- W2002518761 cites W1999831098 @default.
- W2002518761 cites W2000187406 @default.
- W2002518761 cites W2002766976 @default.
- W2002518761 cites W2002946739 @default.
- W2002518761 cites W2005963845 @default.
- W2002518761 cites W2007840060 @default.
- W2002518761 cites W2009804171 @default.
- W2002518761 cites W2013584852 @default.
- W2002518761 cites W2020969391 @default.
- W2002518761 cites W2021689495 @default.
- W2002518761 cites W2026910705 @default.
- W2002518761 cites W2027275966 @default.
- W2002518761 cites W2029655229 @default.
- W2002518761 cites W2031847166 @default.
- W2002518761 cites W2033454577 @default.
- W2002518761 cites W2034432190 @default.
- W2002518761 cites W2037953803 @default.
- W2002518761 cites W2038128569 @default.
- W2002518761 cites W2039093900 @default.
- W2002518761 cites W2043950060 @default.
- W2002518761 cites W2046808547 @default.
- W2002518761 cites W2048252195 @default.
- W2002518761 cites W2059173444 @default.
- W2002518761 cites W2062772596 @default.
- W2002518761 cites W2071573253 @default.
- W2002518761 cites W2071605378 @default.
- W2002518761 cites W2077252116 @default.
- W2002518761 cites W2077292866 @default.
- W2002518761 cites W2080155427 @default.
- W2002518761 cites W2083145603 @default.
- W2002518761 cites W2083827260 @default.
- W2002518761 cites W2085676612 @default.
- W2002518761 cites W2088823531 @default.
- W2002518761 cites W2089311601 @default.
- W2002518761 cites W2092308558 @default.
- W2002518761 cites W2095007914 @default.
- W2002518761 cites W2095912071 @default.
- W2002518761 cites W2099313405 @default.
- W2002518761 cites W2101106024 @default.
- W2002518761 cites W2102313656 @default.
- W2002518761 cites W2120299070 @default.
- W2002518761 cites W2121429506 @default.
- W2002518761 cites W2121876008 @default.
- W2002518761 cites W2126548672 @default.
- W2002518761 cites W2129314972 @default.
- W2002518761 cites W2129617079 @default.
- W2002518761 cites W2130259269 @default.
- W2002518761 cites W2138562294 @default.
- W2002518761 cites W2138907299 @default.
- W2002518761 cites W2139467936 @default.
- W2002518761 cites W2140619393 @default.
- W2002518761 cites W2141178462 @default.
- W2002518761 cites W2141310245 @default.
- W2002518761 cites W2150518449 @default.
- W2002518761 cites W2151011478 @default.
- W2002518761 cites W2152286256 @default.
- W2002518761 cites W2153027227 @default.
- W2002518761 cites W2155849359 @default.
- W2002518761 cites W2156891963 @default.
- W2002518761 cites W2156999957 @default.
- W2002518761 cites W2158258554 @default.
- W2002518761 cites W2161092951 @default.
- W2002518761 cites W2163848345 @default.
- W2002518761 cites W2164589411 @default.
- W2002518761 cites W2165291913 @default.