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- W2002531150 abstract "THE RESULTS of experiments in laboratory animals clearly demonstrate that tumor tissues transplanted between rodents possessing identical histocompatibility antigens can lead to immunologic rejection of the tumor. This has led many investigators to propose that tumors, including spontaneously occurring tumors in man, must result, at least in part, from failure of the immune response of the host to recognize and subsequently destroy cells bearing tumor antigens. This concept of immune surveillance has been invoked as a major mechanism for eradication of spontaneously arising tumor cells in otherwise normal persons, and as an explanation for the exceptionally high incidence of tumors in patients with immune deficiency syndromes and recipients of immunosuppressive therapy. In applying the hypothesis that arose from observations in animal systems to the cancers that afflict man, the following points must be kept in mind. In most experiments, it has been necessary to sensitize the recipient animals with dead" @default.
- W2002531150 created "2016-06-24" @default.
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- W2002531150 date "1982-11-26" @default.
- W2002531150 modified "2023-10-17" @default.
- W2002531150 title "Tumor Immunology" @default.
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- W2002531150 doi "https://doi.org/10.1001/jama.1982.03330200146027" @default.
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