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• W2002531486 abstract "In Brief Objective: The aim of this study was to analyze the determinants of breast discomfort among postmenopausal women initiating menopausal hormone therapy (HT). Methods: We analyzed questionnaire, anthropometric, and serum estrone data from the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial, a randomized trial comparing placebo, conjugated equine estrogens (CEE) alone, or CEE with a progestogen (continuous or cyclical medroxyprogesterone acetate or cyclical micronized progesterone) among postmenopausal women. HT users could join the PEPI Trial after stopping HT for 2 months. We modeled the relation between smoking, body weight, alcohol consumption, age, quitting HT for the PEPI Trial, physical activity, and α-tocopherol consumption and new-onset breast discomfort at the 12-month follow-up among 662 participants without baseline breast discomfort. Results: The associations of new-onset breast discomfort with weight and with strenuous exercise varied by treatment assignment. Among women assigned to CEE + progestogen, strenuous exercise was associated with a 49% lower odds of new-onset breast discomfort (odds ratio, 0.51; 95% CI, 0.29-0.89; P = 0.02), whereas among women assigned to placebo or CEE alone, strenuous exercise was not significantly associated with new-onset breast discomfort. Surprisingly, among women taking CEE alone, each kilogram higher weight was associated with a 6% lower odds of new-onset breast discomfort (P = 0.04), whereas among women taking placebo, the association was in the opposite direction (P = 0.04). Adjustment for estrone level had negligible effects on odds ratios. α-Tocopherol intake, age, smoking, and alcohol intake were not significantly associated with new-onset breast discomfort in adjusted analyses. Conclusions: Strenuous exercise and higher body weight may decrease the odds of new-onset breast discomfort among postmenopausal women initiating HT. This study analyzed data from a trial comparing the effects of placebo, conjugated equine estrogens alone, or conjugated equine estrogens plus progestogen among postmenopausal women. Self-reported strenuous exercise and higher body weight were each associated with significantly lower odds of experiencing new-onset of breast tenderness after hormone therapy initiation." @default.
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• W2002531486 date "2010-05-01" @default.
• W2002531486 modified "2023-09-22" @default.
• W2002531486 title "Predictors of breast discomfort among women initiating menopausal hormone therapy" @default.
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• W2002531486 doi "https://doi.org/10.1097/gme.0b013e3181c29e68" @default.
• W2002531486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2866780" @default.
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