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• W2002531640 abstract "Osteoarthritis (OA) is a common and disabling joint disorder affecting millions of people worldwide. In OA, pathological changes are seen in all of the joint tissues including bone. Although both cross-sectional and longitudinal epidemiological studies have consistently demonstrated an association between higher bone mineral density (BMD) and OA, suggesting that increased BMD is a risk factor for OA, the mechanisms underlying this observation remain unclear. Recently, novel approaches to examining the BMD-OA relationship have included studying the disease in individuals with extreme high bone mass, and analyses searching for genetic variants associated with both BMD variation and OA, suggesting possible pleiotropic effects on bone mass and OA risk. These studies have yielded valuable insights into potentially relevant pathways that might one day be exploited therapeutically. Although animal models have suggested that drugs reducing bone turnover (antiresorptives) may retard OA progression, it remains to be seen whether this approach will prove to be useful in human OA. Identifying individuals with a phenotype of OA predominantly driven by increased bone formation could help improve the overall response to these treatments. This review aims to summarise current knowledge regarding the complex relationship between BMD and OA." @default.
• W2002531640 created "2016-06-24" @default.
• W2002531640 creator A5013184354 @default.
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• W2002531640 creator A5048062868 @default.
• W2002531640 creator A5079064941 @default.
• W2002531640 date "2015-01-21" @default.
• W2002531640 modified "2023-09-27" @default.
• W2002531640 title "Osteoarthritis and bone mineral density: are strong bones bad for joints?" @default.
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• W2002531640 doi "https://doi.org/10.1038/bonekey.2014.119" @default.
• W2002531640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4303262" @default.
• W2002531640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25628884" @default.
• W2002531640 hasPublicationYear "2015" @default.
• W2002531640 type Work @default.
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