FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002536280> ?p ?o ?g. }

• W2002536280 endingPage "e1417" @default.
• W2002536280 startingPage "e1417" @default.
• W2002536280 abstract "MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cell survival and proliferation. Depletion of MEIS2 in neuroblastoma cells leads to M-phase arrest and mitotic catastrophe, whereas ectopic expression of MEIS2 markedly enhances neuroblastoma cell proliferation, anchorage-independent growth, and tumorigenicity. Gene expression profiling reveals an essential role of MEIS2 in maintaining the expression of a large number of late cell-cycle genes, including those required for DNA replication, G2-M checkpoint control and M-phase progression. Importantly, we identify MEIS2 as a transcription activator of the MuvB-BMYB-FOXM1 complex that functions as a master regulator of cell-cycle gene expression. Further, we show that FOXM1 is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes. These findings link a developmentally important gene to the control of cell proliferation and suggest that high MEIS2 expression is a molecular mechanism for high expression of mitotic genes that is frequently observed in cancers of poor prognosis." @default.
• W2002536280 created "2016-06-24" @default.
• W2002536280 creator A5004378997 @default.
• W2002536280 creator A5011653200 @default.
• W2002536280 creator A5023566659 @default.
• W2002536280 creator A5024729608 @default.
• W2002536280 creator A5050155862 @default.
• W2002536280 creator A5051246779 @default.
• W2002536280 creator A5055014462 @default.
• W2002536280 creator A5056338545 @default.
• W2002536280 creator A5059905480 @default.
• W2002536280 date "2014-09-11" @default.
• W2002536280 modified "2023-10-17" @default.
• W2002536280 title "MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression" @default.
• W2002536280 cites W1642411512 @default.
• W2002536280 cites W1666476357 @default.
• W2002536280 cites W1767351348 @default.
• W2002536280 cites W1970461933 @default.
• W2002536280 cites W1971579914 @default.
• W2002536280 cites W1985647633 @default.
• W2002536280 cites W1987572677 @default.
• W2002536280 cites W1990474127 @default.
• W2002536280 cites W1994363752 @default.
• W2002536280 cites W1994564000 @default.
• W2002536280 cites W1997367417 @default.
• W2002536280 cites W1999655524 @default.
• W2002536280 cites W2002512110 @default.
• W2002536280 cites W2010790391 @default.
• W2002536280 cites W2025718369 @default.
• W2002536280 cites W2026143081 @default.
• W2002536280 cites W2029139186 @default.
• W2002536280 cites W2030864103 @default.
• W2002536280 cites W2031375485 @default.
• W2002536280 cites W2033795508 @default.
• W2002536280 cites W2034091087 @default.
• W2002536280 cites W2034980302 @default.
• W2002536280 cites W2042889829 @default.
• W2002536280 cites W2047219888 @default.
• W2002536280 cites W2047710219 @default.
• W2002536280 cites W2047790147 @default.
• W2002536280 cites W2050717449 @default.
• W2002536280 cites W2051961268 @default.
• W2002536280 cites W2067606868 @default.
• W2002536280 cites W2079965169 @default.
• W2002536280 cites W2080823011 @default.
• W2002536280 cites W2098159639 @default.
• W2002536280 cites W2106713259 @default.
• W2002536280 cites W2124006755 @default.
• W2002536280 cites W2130410032 @default.
• W2002536280 cites W2130925781 @default.
• W2002536280 cites W2134051389 @default.
• W2002536280 cites W2135202855 @default.
• W2002536280 cites W2135630561 @default.
• W2002536280 cites W2145900952 @default.
• W2002536280 cites W2148634906 @default.
• W2002536280 cites W2150048195 @default.
• W2002536280 cites W2153593562 @default.
• W2002536280 cites W2154882012 @default.
• W2002536280 cites W2155768517 @default.
• W2002536280 cites W2158217645 @default.
• W2002536280 cites W2164660906 @default.
• W2002536280 cites W2166651826 @default.
• W2002536280 cites W2171482205 @default.
• W2002536280 doi "https://doi.org/10.1038/cddis.2014.370" @default.
• W2002536280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4540202" @default.
• W2002536280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25210800" @default.
• W2002536280 hasPublicationYear "2014" @default.
• W2002536280 type Work @default.
• W2002536280 sameAs 2002536280 @default.
• W2002536280 citedByCount "44" @default.
• W2002536280 countsByYear W20025362802014 @default.
• W2002536280 countsByYear W20025362802015 @default.
• W2002536280 countsByYear W20025362802016 @default.
• W2002536280 countsByYear W20025362802017 @default.
• W2002536280 countsByYear W20025362802018 @default.
• W2002536280 countsByYear W20025362802019 @default.
• W2002536280 countsByYear W20025362802020 @default.
• W2002536280 countsByYear W20025362802021 @default.
• W2002536280 countsByYear W20025362802022 @default.
• W2002536280 countsByYear W20025362802023 @default.
• W2002536280 crossrefType "journal-article" @default.
• W2002536280 hasAuthorship W2002536280A5004378997 @default.
• W2002536280 hasAuthorship W2002536280A5011653200 @default.
• W2002536280 hasAuthorship W2002536280A5023566659 @default.
• W2002536280 hasAuthorship W2002536280A5024729608 @default.
• W2002536280 hasAuthorship W2002536280A5050155862 @default.
• W2002536280 hasAuthorship W2002536280A5051246779 @default.
• W2002536280 hasAuthorship W2002536280A5055014462 @default.
• W2002536280 hasAuthorship W2002536280A5056338545 @default.
• W2002536280 hasAuthorship W2002536280A5059905480 @default.
• W2002536280 hasBestOaLocation W20025362801 @default.
• W2002536280 hasConcept C104317684 @default.
• W2002536280 hasConcept C1491633281 @default.
• W2002536280 hasConcept C2776715637 @default.
• W2002536280 hasConcept C29537977 @default.
• W2002536280 hasConcept C502942594 @default.
• W2002536280 hasConcept C54355233 @default.
• W2002536280 hasConcept C555283112 @default.

• next